Evidence map›Paper›PMID 41003018›Full record

ArticleMetabolites2025

Deciphering the Role of Different Ceramide Synthases in the Human Cardiomyocyte Hypertrophic Response.

Alexandra M Wiley, Melissa A Krueger, Nona Sotoodehnia, Jason G Umans, Andrew N Hoofnagle, Rozenn N Lemaitre, Rheem A Totah, Sina A Gharib

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. The Role of Ceramides in Metabolic and Cardiovascular Diseases.Journal of cardiovascular development and disease · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexandra M WileyDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
Melissa A KruegerComputational Medicinal Core, Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0002-6276-3463
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, Division of Cardiology, University of Washington, Seattle, WA 98195, USA.
Jason G UmansMedStar Health Research Institute, Hyattsville, MD 21044, USA.ORCID 0000-0002-2746-3350
Andrew N HoofnagleDepartment of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-6449-0243
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-7038-1844
Rheem A TotahDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-1664-4874
Sina A GharibComputational Medicinal Core, Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0002-2480-4367

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON · 1986 to 2026
$30.4M
Plasma Sphingolipids and Subclinical and Clinical Cardiovascular DiseaseR01HL146499 · NHLBI · UNIVERSITY OF WASHINGTON · PI LEMAITRE, ROZENN · 2020 to 2023
$2.7M
NHLBI NIH HHS R01 HL146499NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIH HHS NORC grant P30 DK035816 and R01 HL146499
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiac hypertrophycardiovascular diseasecell signalingceramideslipidssphingolipidstranscriptomics

Identifiers

PMID41003018
PMCPMC12471689

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.