Evidence mapPaperPMID 41003307Full record

ArticleMarine drugs2025

Marine Algal Metabolites as Cellular Antioxidants: A Study of Caulerpin and Caulerpinic Acid in

Graziana Assalve, Paola Lunetti, Annalisa Fai, Antonio Terlizzi, Vincenzo Zara, Alessandra Ferramosca

Erratum issuedAbstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Graziana AssalveDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.ORCID 0009-0002-0165-7920
Paola LunettiDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.ORCID 0000-0001-7118-1994
Annalisa FaiDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.
Antonio TerlizziDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Vincenzo ZaraDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.
Alessandra FerramoscaDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.ORCID 0000-0002-8251-9652

Funding

CIB (Consorzio Interuniversitario per le Biotecnologie) MUR DM 581/22Italian Ministry of University and Research Project code CN_00000033, Concession Decree No. 1034 of 17 June 2022 adopted by the Italian Ministry of University and Research, CUP F87G22000290001, Project title "National Biodiversi-ty Future Center - NBFC"
6 · The paper itself

Abstract

Oxidative stress caused by excessive reactive oxygen species (ROS) contributes to numerous chronic diseases. Marine green algae of the

objectiveThis study aimed to evaluate the intracellular antioxidant effects of caulerpin (CAU) and its derivative caulerpinic acid (CA) using

methodsYeast cells were pretreated with 1 μM of CAU or CA, or with 1 μM of resveratrol (RESV) as a positive control, then exposed to 2 mM of H

resultsBoth CAU and CA significantly improved cell survival under oxidative stress, restoring growth rates (CAU: 0.129 h

conclusionsCAU and CA act as effective intracellular antioxidants, primarily via ROS scavenging and GSH-dependent pathways. These findings support their potential as natural candidates for developing antioxidant-based therapies against ROS-related disorders.

Indexed as

AntioxidantsCaulerpaSaccharomyces cerevisiaeAquatic OrganismsCatalaseGlutathioneGlutathione PeroxidaseHydrogen PeroxideLipid PeroxidationOxidative StressReactive Oxygen SpeciesSuperoxide DismutaseAntioxidantsCatalaseGlutathioneGlutathione PeroxidaseHydrogen PeroxideReactive Oxygen SpeciesSuperoxide Dismutasealgal metabolitesantioxidantsCaulerpaoxidative stressS. cerevisiae

Identifiers

PMID41003307
PMCPMC12471837

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.