Evidence map›Paper›PMID 41003331›Full record

ArticleMarine drugs2025

Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea

Emmanuel Tope Oluwabusola, Stephen A Jackson, Cristina Brunati, Stefanie Gackstatter, Hannah Vedder, Marianna Iorio, Gargee Chawande, Lekha Menon Margassery, Giang-Son Nguyen, David J Clarke and 3 more

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emmanuel Tope OluwabusolaMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3FX, UK.ORCID 0000-0003-3153-4323
Stephen A JacksonSchool of Microbiology, University College Cork, College Road, T12 K8AF Cork, Ireland.ORCID 0000-0001-7869-9032
Cristina BrunatiNAICONS, viale Ortles 22/4, 20139 Milan, Italy.
Stefanie GackstatterInterfaculty Institute of Biochemistry, University of Tübingen, 72076 Tübingen, Germany.
Hannah VedderDepartment of Pharmacy, Philipps University Marburg, 35043 Marburg, Germany.
Marianna IorioNAICONS, viale Ortles 22/4, 20139 Milan, Italy.ORCID 0000-0001-8669-5875
Gargee ChawandeSchool of Microbiology, University College Cork, College Road, T12 K8AF Cork, Ireland.
Lekha Menon MargasserySchool of Microbiology, University College Cork, College Road, T12 K8AF Cork, Ireland.ORCID 0000-0003-1590-0012
Giang-Son NguyenDepartment of Biotechnology and Nanomedicine, SINTEF Industry, 7034 Trondheim, Norway.ORCID 0000-0001-5730-3326
David J ClarkeSchool of Microbiology, University College Cork, College Road, T12 K8AF Cork, Ireland.ORCID 0000-0001-9082-0501
Rainer EbelMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3FX, UK.ORCID 0000-0002-9702-2235
Marcel JasparsMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3FX, UK.ORCID 0000-0002-2426-6028
Alan D W DobsonSchool of Microbiology, University College Cork, College Road, T12 K8AF Cork, Ireland.ORCID 0000-0002-7713-5574

Funding

BBSRC UK ALERT-22 Scheme BB/X019802/1European Union's Horizon 2020 research and innovation programme 101000392
6 · The paper itself

Abstract

Using the one-strain-many-compounds (OSMAC) culturing approach, metabolomic studies, and bioassay-guided purification, we have isolated and characterised three new chlorinated natural products, agelolines B-D (

Indexed as

Anti-Bacterial AgentsBiological ProductsStreptomycesAnimalsAquatic OrganismsDrug DiscoveryHalogenationHumansMetabolomicsMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsBiological Productsantimicrobial activityA. salmonicidafeature-based molecular networkinghalogenated compoundlipopeptidesmetaboanalystStreptomyces spp.

Identifiers

PMID41003331
PMCPMC12471526

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.