Evidence mapPaperPMID 41003392Full record

ReviewJournal of functional biomaterials2025

A Histological and Clinical Evaluation of Long-Term Outcomes of Bovine Bone-Derived Xenografts in Oral Surgery: A Systematic Review.

Angelo Michele Inchingolo, Grazia Marinelli, Irma Trilli, Gaetano Del Vecchio, Angela Di Noia, Francesco Inchingolo, Massimo Del Fabbro, Andrea Palermo, Alessio Danilo Inchingolo, Gianna Dipalma

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0104-6337
Grazia MarinelliDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-9163-2350
Irma TrilliDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-2882-025X
Gaetano Del VecchioDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0009-0009-1197-9721
Angela Di NoiaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0009-0004-0933-8670
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Massimo Del FabbroDepartment of Biomedical, Surgical and Dental Sciences, Milan University, 20122 Milan, Italy.ORCID 0000-0001-7144-0984
Andrea PalermoDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6366-1039
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBovine bone-derived xenografts are widely used in regenerative dental procedures due to their osteoconductive properties and volumetric stability. However, their long-term behavior and biological integration remain a subject of debate. This systematic review aims to critically assess the histological and clinical outcomes associated with bovine xenografts over extended follow-up periods.

methodsAn electronic search was performed in PubMed, Scopus, and Web of Science, including studies published in the English language from 2005 to 2025 for a total of 217 records, which were initially identified from PubMed, Scopus, and Wos.

resultsAfter duplicate removal, following title/abstract screening and full-text evaluation, 11 studies met the inclusion criteria. These studies reported on the use of bovine-derived xenografts in clinical contexts, assessing parameters such as graft integration, histological remodeling, complication incidence (e.g., chronic inflammation or foreign body reactions), and implant success rates over time.

conclusionsThe current evidence suggests that bovine-derived xenografts, particularly Bio-Oss

Indexed as

Bio-Ossbone regenerationbovine bone graftbovine-derived xenograftclinical outcomescomplicationsfollow-upGBRguided bone regenerationhistological evaluationlong-termxenograft

Identifiers

PMID41003392
PMCPMC12470767

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.