Evidence mapPaperPMID 41003424Full record

ReviewJournal of functional biomaterials2025

Clinical Efficacy of Clear Aligners in Class II Malocclusion: From Pediatric to Adult Cases-A Narrative Review.

Gianna Dipalma, Grazia Marinelli, Francesco Inchingolo, Marialuisa Longo, Maral Di Giulio Cesare, Sharon Di Serio, Andrea Palermo, Massimo Del Fabbro, Alessio Danilo Inchingolo, Angelo Michele Inchingolo

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gianna DipalmaInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Grazia MarinelliInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-9163-2350
Francesco InchingoloInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Marialuisa LongoInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Maral Di Giulio CesareInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0009-0006-2521-6627
Sharon Di SerioInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Andrea PalermoDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.ORCID 0000-0002-3288-490X
Massimo Del FabbroDepartment of Biomedical, Surgical and Dental Sciences, Milan University, 20122 Milan, Italy.ORCID 0000-0001-7144-0984
Alessio Danilo InchingoloInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6366-1039
Angelo Michele InchingoloInterdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0104-6337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClass II malocclusion is one of the most common and challenging orthodontic problems, often requiring complex, lengthy treatment and sometimes involving extractions or surgery. While conventional fixed appliances have been the gold standard, the increasing demand for aesthetic and comfortable treatment alternatives has made clear aligners a prevalent choice. Understanding the specific biomechanics, limitations, and successful clinical strategies for using aligners-especially in managing vertical dimension and achieving skeletal correction (mandibular advancement)-is crucial for expanding non-invasive treatment options and improving outcomes for a broad range of Class II patients.

objectiveThe objective of this review is to examine the effectiveness and clinical approaches of clear aligners in Class II correction across different age groups, with particular attention to vertical control, mandibular advancement methods, and the predictability of tooth movements in both growing and fully mature patients. MATERIALS AND

methodsThis review narratively discusses the most relevant clinical findings and practical strategies for managing Class II malocclusions with clear aligners. Particular attention is given to the integration of auxiliary devices, such as elastics, attachments, and temporary anchorage devices (TADs), which can enhance biomechanical control.

resultsThe combination of aligners with mini-implants and attachments resulted in a consequent decrease in excessive overjet, improvement in facial profile, and long-term stability supported by fixed retention. In growing patients, correction benefited from mandibular advancement protocols and control of molar extrusion, allowing for preservation of the mandibular plane angle. Movement predictability showed higher reliability in anterior torque movements, whereas maxillary incisor intrusion remained less predictable.

conclusionsClear aligners, especially when supported by auxiliary device, such as mini-implants and attachments, offer a reliable and aesthetic alternative to conventional orthodontic treatment for Class II malocclusions. However, certain tooth movements may still be less predictable, highlighting the need for careful planning, individualized biomechanics, and ongoing technological improvements.

Indexed as

alignerClass IIdistalizzationmalocclusion

Identifiers

PMID41003424
PMCPMC12470377

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.