Evidence map›Paper›PMID 41003486›Full record

ArticleTomography (Ann Arbor, Mich.)2025

Evaluation of Magnetization Transfer Contrast Sequences: Application to Monitor Age-Related Differences in Muscle Macromolecular Fraction.

Austin Crispin-Smith, Ti Wu, Ilana R Leppert, Agah Karakuzu, Shantanu Sinha, Usha Sinha

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Austin Crispin-SmithDepartment of Physics, San Diego State University, San Diego, CA 92182, USA.
Ti WuDepartment of Physics, San Diego State University, San Diego, CA 92182, USA.
Ilana R LeppertBrain Imaging Center, Montreal Neurological Institute, Montreal, QC H3A2B4, Canada.ORCID 0000-0001-7672-0918
Agah KarakuzuNeuroPoly Lab, Polytechnique Montreal, Montreal, QC H3T1N8, Canada.
Shantanu SinhaMuscle Imaging and Modeling Laboratory, Department of Radiology, University of California San Diego, San Diego, CA 92037, USA.
Usha SinhaDepartment of Physics, San Diego State University, San Diego, CA 92182, USA.

Funding

Role of the Extracellular Matrix in Age-Associated Strength Loss: Combining Imaging and Biochemistry to create a Multi-Scale Mesh-free ModelR01AG056999 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SINHA, SHANTANU · 2018 to 2022
$3.1M
National Institute of Aging 5R01AG056999NIA NIH HHS R01 AG056999
6 · The paper itself

Abstract

BACKGROUND/

objectivesSeveral sequences for magnetization transfer contrast (MTC) imaging are available, from indices of MTC ranging from quantitative magnetization transfer (qMT) that yields the macromolecular fraction to simple ratios of signal intensities with and without a magnetization transfer (MT) pulse. Aging muscle undergoes changes including an increase in fibrosis and adipose accompanied by fiber atrophy and loss. The objective is to evaluate five MTC sequences to study age-related differences in muscle tissue composition.

methodsThe lower leg (calf) of 15 young (8M/7F, 25.8 ± 3.7 years) and 9 senior subjects (5F/4M, 68.4 ± 3.3 years) was imaged with the following sequences: multi-offset qMT fit to the Ramani and Yarnykh models, single-offset qMT two-parameter fit to the Ramani model, a semi-quantitative

resultsSignificant age-related decreases (

conclusionsAge-related decreases in MTC may reflect that loss of myofibrillar proteins dominates the increase in collagen content with age. Further, the modest correlation of MTC indices with

Indexed as

Macromolecular SubstancesMagnetic Resonance ImagingMusclesAdultAgedAge FactorsFemaleHumansLegMaleMacromolecular Substancesaging musclecalf muscle magnetization transferquantitative magnetization transfer

Identifiers

PMID41003486
PMCPMC12473340

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.