ArticleMetabolomics : Official journal of the Metabolomic Society2025
Metabolic remodeling and its hidden heterogeneity in uterine fibroids: comprehensive metabolomic profiling and mass spectrometry imaging.
Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Dive into the Invisible: The Vaginal and Endometrial Microbiota in Gynecologic and Obstetric Disorders: A Narrative Review.Life (Basel, Switzerland) · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
introductionAs the most common benign gynecological tumor in women, uterine fibroids not only pose a serious threat to reproductive health but also directly impair fertility. The structural abnormalities of the uterus and metabolic disturbances they induce have become critical pathological contributors to infertility, recurrent miscarriage, and obstetric complications in reproductive-aged women. However, the underlying metabolic mechanisms of uterine fibroids remain poorly understood.
objectiveThis study aimed to explore metabolic remodeling of uterine fibroids from patients.
methodsWe performed global metabolomics analysis on myometrium and uterine fibroid tissues by combining ultra-high performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) analysis and gas chromatography coupled with mass spectrometry (GC-MS) analysis. Spatially resolved metabolomics was carried out to analyze intratumor metabolic heterogeneity via desorption electrospray ionization mass spectrometry imaging (DESI-MSI). Combined with machine learning, important metabolites related to uterine fibroids were identified.
resultsThis study enabled mapping a comprehensive metabolome atlas up to 825 metabolites in human myometrium and uterine fibroid tissues via combining UHPLC-MS with GC-MS. Metabolic shifts from myometrium to uterine fibroids were clearly observed, which was accompanied by large changes in metabolites and amino acid metabolic pathways to display metabolic remodeling of uterine fibroids. Combined with machine learning, a total of ten metabolites were identified to characterize metabolic properties of uterine fibroids. Furthermore, DESI-MSI was employed to effectively differentiate regions of hyaline degeneration from those devoid of such degeneration, thereby firstly highlighting the intrinsic metabolic heterogeneity present in uterine fibroids.
conclusionThe findings offer new insights into the metabolic pathophysiology of fibroids, which may aid in the development of targeted therapeutic strategies for this widespread gynecological disorder.
Indexed as
Identifiers
41003804What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.