Evidence map›Paper›PMID 41003813›Full record

ArticleJournal of molecular histology2025

Morphological and histopathological study of edible bird's nest on wound healing in mice.

Min Li, Bo Liu, Man Yuan, Xiaoli Dai, Shuang Qiu, Xiangkui Zhang, Xiaoyang Zheng, Kai Chen, Chonggang Duan, Daizhou Zhang and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Min LiShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China.
Bo LiuShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China.
Man YuanHebei Edible Bird's Nest Fresh Stew Technology Innovation Center, Langfang, 065700, China.
Xiaoli DaiShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China.
Shuang QiuHebei Edible Bird's Nest Fresh Stew Technology Innovation Center, Langfang, 065700, China.
Xiangkui ZhangShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China.
Xiaoyang ZhengShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China.
Kai ChenShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China.
Chonggang DuanShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China.
Daizhou ZhangShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China.
Dongliang WangHebei Edible Bird's Nest Fresh Stew Technology Innovation Center, Langfang, 065700, China. dongliang.wang@xxdun.com.
Xiangjing MengShandong Engineering Research Center of Skin and Mucosa Drug Administration, Shandong Academy of Pharmaceutical Sciences, Jinan, 250100, China. fredamxj@163.com.

Funding

Shandong Academy of Pharmaceutical Sciences HZ22004
6 · The paper itself

Abstract

Edible bird's nest (EBN) has a variety of pharmacological effects, such as improving immunity, antioxidant, promoting brain development, nerve prevention, degenerative diseases, and whitening and moisturizing skin, but its role in wound healing is still unknown. In this study, full-thickness excisional wounds were made on the back of mice to establish the wound model. The mice were treated with EBN, a positive drug, and 0.9% NaCl for 14 days. At days 3, 7, and 14 post-injury, the traumatic skin and intestinal contents of mice were collected. ELISA, western blot and quantitative PCR assay were used to evaluate the expression of inflammatory factor, protein, and mRNA. The damaged skin of the mice was analyzed by histopathology. Biochemical experiment was used to evaluate the content of hydroxyproline. Gas chromatograph was used to detect mouse intestinal contents. Results showed that EBN can narrow the wound area, reduce the expression of inflammatory factors, upregulate the expression of collagen and α-SMA, improve the damaged skin structure, increase the content of SCFAs and promote wound recovery rapidly. Current findings may suggest that EBN might serve as a potential effective substance for wound healing therapy either orally or externally.

Indexed as

BirdsWound HealingAnimalsDisease Models, AnimalMaleMiceSkinCollagenEdible bird’s nestInflammatory factorsMice skinWound healing

Identifiers

PMID41003813
PMCPMC12474635

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.