Evidence map›Paper›PMID 41003941›Full record

ReviewLa Radiologia medica2025

Ultra-low-field MRI: a David versus Goliath challenge in modern imaging.

Cesare Gagliardo, Paola Feraco, Eleonora Contrino, Costanza D'Angelo, Laura Geraci, Giuseppe Salvaggio, Andrea Gagliardo, Ludovico La Grutta, Massimo Midiri, Maurizio Marrale

Abstract readReview
In one paragraph

Review in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cesare GagliardoDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, Via del Vespro, 129, 90127, Palermo, Italy. cesare.gagliardo@unipa.it.ORCID http://orcid.org/0000-0003-4088-2020
Paola FeracoCentre for Medical Sciences (CISMed), University of Trento, Trento, Italy.ORCID http://orcid.org/0000-0002-3707-018X
Eleonora ContrinoNeuroradiology Unit, University-Hospital Paolo Giaccone, Palermo, Italy.
Costanza D'AngeloDepartment of Precision Medicine in the Medical, Surgical, and Critical Care Area (MePreCC), University of Palermo, Palermo, Italy.
Laura GeraciNeuroradiology Unit, Department of Radiological Sciences, A.R.N.A.S. Civico, Palermo, Italy.
Giuseppe SalvaggioRadiology Unit, University-Hospital Paolo Giaccone, Palermo, Italy.ORCID http://orcid.org/0000-0003-2465-1185
Andrea GagliardoDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, Via del Vespro, 129, 90127, Palermo, Italy.
Ludovico La GruttaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, Italy.
Massimo MidiriDepartment of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, Via del Vespro, 129, 90127, Palermo, Italy.
Maurizio MarraleDepartment of Physics and Chemistry "Emilio Segrè", University of Palermo, Palermo, Italy.ORCID http://orcid.org/0000-0002-0091-3243

Funding

Ministero della Salute PNC-E3-2022-23683266
6 · The paper itself

Abstract

Ultra-low-field magnetic resonance imaging (ULF-MRI), operating below 0.2 Tesla, is gaining renewed interest as a re-emerging diagnostic modality in a field dominated by high- and ultra-high-field systems. Recent advances in magnet design, RF coils, pulse sequences, and AI-based reconstruction have significantly enhanced image quality, mitigating traditional limitations such as low signal- and contrast-to-noise ratio and reduced spatial resolution. ULF-MRI offers distinct advantages: reduced susceptibility artifacts, safer imaging in patients with metallic implants, low power consumption, and true portability for point-of-care use. This narrative review synthesizes the physical foundations, technological advances, and emerging clinical applications of ULF-MRI. A focused literature search across PubMed, Scopus, IEEE Xplore, and Google Scholar was conducted up to August 11, 2025, using combined keywords targeting hardware, software, and clinical domains. Inclusion emphasized scientific rigor and thematic relevance. A comparative analysis with other imaging modalities highlights the specific niche ULF-MRI occupies within the broader diagnostic landscape. Future directions and challenges for clinical translation are explored. In a world increasingly polarized between the push for ultra-high-field excellence and the need for accessible imaging, ULF-MRI embodies a modern "David versus Goliath" theme, offering a sustainable, democratizing force capable of expanding MRI access to anyone, anywhere.

Indexed as

Magnetic Resonance ImagingHumansSignal-To-Noise RatioInnovationMagnetic resonance imaging (MRI)NeuroimagingPoint-of-care systemsPortable MRI (pMRI)Ultra-low-field MRI (ULF-MRI)

Identifiers

PMID41003941
PMCPMC12669372

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.