Evidence map›Paper›PMID 41004015›Full record

ReviewSub-cellular biochemistry2025

The Hidden Influences of Macromolecular Crowding: A New Frontier in Cellular Biology and Medicine.

Isabella V Gimón, Conner Sandefur, Santiago Schnell

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Isabella V GimónIntegrated Biomedical Sciences Program, University of Notre Dame, Indiana, USA.
Conner SandefurSandefur Modeling, Pittsboro, NC, USA.
Santiago SchnellDepartment of Biological Sciences, and Department of Applied & Computational Mathematics & Statistics, University of Notre Dame, Notre Dame, IN, USA. santiago.schnell@nd.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macromolecular crowding, the dense packing of macromolecules within cells, significantly influences enzyme kinetics, cell signaling, liquid-liquid phase separation, and disease progression. This review explores the multifaceted effects of crowding on osmotic balance, intracellular compartmentalization, and metabolic efficiency. We highlight the exclusion volume effect's role in protein folding, stability, and osmotic homeostasis. Crowding also modulates enzyme activity and kinetics, contributing to metabolic regulation, and plays a crucial role in forming membraneless organelles. Dysregulation of macromolecular crowding is implicated in neurodegenerative diseases, cancer, and type 2 diabetes, highlighting its importance for therapeutic development. Future research should focus on elucidating crowding mechanisms, developing in vivo models, and exploring therapeutic interventions targeting macromolecular crowding.

Indexed as

Diabetes Mellitus, Type 2Macromolecular SubstancesNeoplasmsNeurodegenerative DiseasesAnimalsHumansOrganellesProtein FoldingMacromolecular SubstancesCell biologyCell signalingDiseaseEnzyme kineticsLiquid-liquid phase separationMacromolecular crowdingProtein aggregationTherapeutics

Identifiers

PMID41004015

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.