ReviewSub-cellular biochemistry2025
Differential Expression of Lamins and Modulation of Chromatin Architecture in Carcinogenesis: tous pour un et un pour tous.
Review in Sub-cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Lamins are intermediate filament proteins of the nucleus that are present in nuclear lamina as well as nucleoplasm. They play diverse roles in maintaining the structure and rigidity of the nucleus as well as nuclear homeostasis. Lamins are of two main types-A and B. B-type lamins are expressed from the embryonic stage, whereas A-type lamins are expressed during cell differentiation. Both A- and B-type lamins form distinct but interacting networks that contribute to differential chromosome tethering and distribution within the nucleus. A- and B-type lamins maintain the euchromatin-to-heterochromatin ratio in health and disease. Interestingly, lamin A/B itself varies largely and distinctly in different types of cancer. Likewise, the lamina-associated domains of the chromatin network get significantly altered in the process of carcinogenesis. We have discussed here the differential expression of lamin proteins in different cancers, contributing to distinct genome organization, ultimately precipitating into diverse neoplastic transformation.
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41004041What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.