Evidence map›Paper›PMID 41004079›Full record

ReviewAdvances in experimental medicine and biology2025

Efferocytosis in Homeostasis.

Christian Maueröder, Caitlin M Gillis, Kodi S Ravichandran

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Danger at the border: Rac turns nibblers into murderers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. A century of cell death research.Journal of cell science · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christian MaueröderVIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium.
Caitlin M GillisVIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium.
Kodi S RavichandranVIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium. kodi@wustl.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apoptotic cells are removed by professional and nonprofessional phagocytes via the process of "efferocytosis." Efferocytosis is highly efficient such that accumulation of dead cells is rarely seen in healthy tissues, even though our bodies remove 200-400 billion apoptotic cells daily. Besides clearing apoptotic cells, efferocytosis also has many beneficial roles, including secretion of anti-inflammatory mediators and promotion of local tissue repair. Thus, impairments in efferocytosis interfere with normal function in tissues. In this review, we will focus on how efferocytosis supports the return to homeostasis following inflammation and injury. Further, we highlight maladaptive responses when efferocytosis is disrupted, contributing to autoimmunity and fibrosis.

Indexed as

ApoptosisHomeostasisPhagocytesPhagocytosisAnimalsEfferocytosisFibrosisHumansInflammationApoptosisAsthmaDead cell clearance in the testesEfferocytosisFibrosisHomeostasisImmune toleranceLung inflammationMammary involutionSLETissue repair

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.