ReviewAdvances in neurobiology2025
Potential Role of Extracellular Vesicles in Mediating Effects of Exercise on Brain Function.
Review in Advances in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Physical Exercise Counteracts Impaired Cognition by Improving Mitochondrial Function.International journal of molecular sciences · 2026Review
- Exercise-conditioned extracellular vesicles in Alzheimer's disease: a multi-organ signaling network linking peripheral adaptation to brain pathology.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise has a remarkable capacity to improve brain function by fostering neuronal plasticity, which enables us to better cope with various psychological and cognitive challenges. Numerous studies have demonstrated the neuroprotective effects of exercise. However, the underlying molecular mechanisms of the neuroprotective effects of exercise are not yet fully understood. In particular, the role of exercise-induced secretion of peripheral factors into circulation that influence the brain is understudied. Recent research has shown that extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, are secreted during exercise. The discovery that EVs can mediate intracellular communication by delivering cargo signifies a promising area of research to understand the impact of exercise on the brain. In the present review, we provide an overview of recent advancements in understanding the regulatory mechanisms of EV biogenesis and discuss how EV molecular composition is influenced by exercise. Additionally, we highlight the potential role of EVs as exercise-specific mediators and as a promising therapeutic tool for neurodegenerative diseases, such as Alzheimer's disease.
Indexed as
Identifiers
41004098What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.