Evidence map›Paper›PMID 41004242›Full record

ArticleAntimicrobial agents and chemotherapy2025

A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against

Guoquan Chen, Wanfei Li, Ka Hei Lam, Mingyue Hu, Qian Wu, Xiangyu Xu, Yunzhu Huang, Fei Tang, Guohui Cui, Ping Cui and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Guoquan Chen *College of Animal Science and Technology, Guangxi University, Nanning, China.
Wanfei Li *School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
Ka Hei LamSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.
Mingyue HuDepartment of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Qian WuDepartment of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Xiangyu XuDepartment of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yunzhu HuangDepartment of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Fei TangDepartment of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Guohui CuiDepartment of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Ping CuiLife Science Institute, Guangxi Medical University, Nanning, China.
Jianping ZuoLaboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Linna LiuInstitute of Infectious Disease, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0003-4122-9998
Jun QianDepartment of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0001-9965-8969
Hong-Jie ZhangSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China.ORCID 0000-0002-7175-5166
Yi-Ping LiDepartment of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0001-6011-3101

Funding

The High-Level Foreign Expert Introduction Project of Ministry of S&T of China G2023162006LThe Innovation and Technology Commission of Hong Kong Special Administrative Region, China GHP/206/22GDThe Natural Science Foundation of Guangdong Province, China 2024A1515013062, 20251515012704The Research Grants Council of the Hong Kong Special Administrative Region, China HKBU12103021The Science and Technology Planning Project of Guangdong Province, China 2021B1212040017The Science and Technology Planning Project of Guangdong Province, China 2022B1212060001, 2023B1212130001, 2024B1212160001The Science and Technology Planning Project of Guangdong Province, China 2023A0505050091
6 · The paper itself

Abstract

Dengue virus (DENV) represents a significant public health threat, with its four serotypes estimated to account for approximately 96 million symptomatic infections annually. Currently, there are no antiviral agents available for the prevention or treatment of DENV infection. Here, we initially screened 12 diphyllin derivatives and identified C156-P1, a nitrogen-containing compound, as a potent agent against DENV infection. Further, C156-P1 exhibited inhibitory effects against the viruses of the

Indexed as

Antiviral AgentsEndosomesFlaviviridaeAnimalsCell LineChlorocebus aethiopsDengue VirusEncephalitis Virus, JapaneseHepacivirusHumansMiceNitrogenVacuolar Proton-Translocating ATPasesVero CellsVirus InternalizationVirus ReplicationAntiviral AgentsNitrogenVacuolar Proton-Translocating ATPasesdengue virusFlaviviridae virusesnitrogen-containing diphyllin derivativesplant natural products

Identifiers

PMID41004242
PMCPMC12587552

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.