Observational studyActa anaesthesiologica Scandinavica2025
Patient Characteristics Associated With Outcomes After General Anaesthesia in Denmark: A Nationwide Observational Study.
Observational study in Acta anaesthesiologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Patient Characteristics Associated With Outcomes After General Anaesthesia in Denmark: A Nationwide Observational Study.Acta anaesthesiologica Scandinavica · 2025Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundSurgery under general anaesthesia is generally safe, although some patients are vulnerable to postoperative complications. Identifying predictors of poor outcomes after general anaesthesia in all settings is relevant for preoperative risk assessment, postoperative monitoring and patient counselling. The aim of this study was to identify patient groups with poor outcomes after general anaesthesia in Denmark.
methodsThis was a nationwide, registry-based, observational cohort study of patients aged 18 years and above undergoing general anaesthesia in Denmark. Associations between patient characteristics (age, sex, body mass index, ASA classification and 23 comorbidities) and outcomes were analysed. The primary outcome was 30-day mortality. Secondary outcomes included acute kidney injury within 7 and 30 days, hospital length of stay, any ICU stay, length of ICU stay, 90-day mortality, in-hospital cardiac arrest within 30 days, and need for mechanical ventilation within 7 days.
resultsA total of 328,951 unique patients undergoing 453,133 cases of general anaesthesia in Denmark during 2020 and 2021 were identified. The adjusted odds of 30-day mortality were higher for cases with higher age, male sex and higher ASA classification. Compared with ASA II, the adjusted odds ratio for 30-day mortality was 0.19 (CI: 0.13-0.29) for ASA I, 7.00 (CI: 5.28-9.29) for ASA III, 40.7 (CI: 29.5-56.0) for ASA IV, and 223 (CI: 161-307) for ASA V.
conclusionIn this nationwide observational cohort study, higher ASA classification, higher age and male sex were independently associated with increased odds of 30-day mortality and several secondary outcomes after general anaesthesia. This study helps identify at-risk patient groups suitable for further studies investigating ways to reduce the risk of complications. EDITORIAL COMMENT: From a national cohort, this analysis presents patient factors which have associations with postoperative mortality. This supports a simple classification for patient grouping where focus for complication prevention or mitigation can be applied.
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