Evidence map›Paper›PMID 41004591›Full record

ArticleScience advances2025

A sensory and motor neuropathy caused by a genetic variant of

Zhe Zhang, Jacek Pilch, Samuel Lundt, Nannan Zhang, Yongchang Chang, Tracey Singer, Dariusz Śladowski, Xiao-Ling Hu, Lijun Zheng, Woo-Ping Ge and 5 more

Abstract readCase Reports
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhe ZhangDalton Cardiovascular Research Center (DCRC), University of Missouri, Columbia, MO, USA.ORCID 0000-0001-8412-1595
Jacek PilchDepartment of Pediatric Neurology, Faculty of Medical Science, Medical University of Silesia, Katowice, Poland.ORCID 0000-0001-6792-0985
Samuel LundtDepartment of Pediatric Neurology, Faculty of Medical Science, Medical University of Silesia, Katowice, Poland.
Nannan ZhangDepartment of Pediatric Neurology, Faculty of Medical Science, Medical University of Silesia, Katowice, Poland.ORCID 0009-0008-8748-5309
Yongchang ChangDepartment of Pediatric Neurology, Faculty of Medical Science, Medical University of Silesia, Katowice, Poland.ORCID 0009-0004-2461-6894
Tracey SingerDepartment of Pediatric Neurology, Faculty of Medical Science, Medical University of Silesia, Katowice, Poland.ORCID 0009-0002-6645-4198
Dariusz ŚladowskiDepartment of Transplantology and Central Tissue Bank, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0002-2453-5160
Xiao-Ling HuChinese Institute for Brain Research, Beijing, China.ORCID 0000-0003-2473-874X
Lijun ZhengChinese Institute for Brain Research, Beijing, China.ORCID 0009-0000-9141-3780
Woo-Ping GeChinese Institute for Brain Research, Beijing, China.ORCID 0000-0001-8219-1055
Hua ZhangDepartment of Medicine, School of Medicine, University of Missouri, Columbia, MO, USA.
De-Pei LiDepartment of Medicine, School of Medicine, University of Missouri, Columbia, MO, USA.
Xianlin HanBarshop Institute for Longevity and Aging Studies and Department of Medicine, University of Texas Health Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-8615-2413
Rafal PloskiDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0001-6286-5526
Shinghua DingDalton Cardiovascular Research Center (DCRC), University of Missouri, Columbia, MO, USA.ORCID 0000-0002-7791-1342

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
The Role of Gliotransmission in Cerebral IschemiaR01NS069726 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI DING, SHINGHUA · 2010 to 2022
$3.3M
Pathogenesis and motor neuron degeneration of a novel disease associated with a P158A mutation in NAMPTR01NS123023 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Shinghua Ding · 2022 to 2026
$2.3M
A novel therapeutic approach for Alzheimer Disease (AD)R21AG080715 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI DING, SHINGHUA · 2023 to 2023
$392k
NIA NIH HHS P30 AG013319NIA NIH HHS R21 AG080715NINDS NIH HHS R01 NS069726NINDS NIH HHS R01 NS123023
6 · The paper itself

Abstract

Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway for nicotinamide adenine dinucleotide (NAD

Indexed as

CytokinesHereditary Sensory and Motor NeuropathyNicotinamide PhosphoribosyltransferaseAnimalsDisease Models, AnimalFemaleHumansMaleMiceMutationMutation, MissensePedigreeCytokinesNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, human

Identifiers

PMID41004591
PMCPMC12467057

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.