ArticleThe American journal of cardiology2026
Rising Burden of Hypertensive Heart Disease Mortality Among Young Adults in the United States, 1999 to 2024.
Article in The American journal of cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Temporal and Regional Trends in Cardiovascular Mortality Associated With Diabetes Mellitus: A Nationwide Analysis From 1999 to 2020 in the United States.Health science reports · 2026Article
- National Patterns of Pulmonary Hypertension Mortality in the United States, 2010 to 2024.The American journal of cardiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Hypertensive heart disease (HHD) is a major contributor to cardiovascular (CV) morbidity and mortality. Once primarily seen in older adults, recent data suggest a rising burden among younger populations. National Center for Health Statistics mortality data for United States adults aged 15 to 44 from 1999 to 2024 were analyzed. Age-adjusted mortality rates were calculated overall and by demographic subgroup, including sex, race, ethnicity, age group, rural and urban residence, state, and Census region. The proportion of HHD mortality relative to other CV disease (CVD) deaths were examined. Joinpoint regression identified annual percent changes and inflection points. From 1999 to 2024, there were 119,264 HHD-related deaths among young adults. HHD mortality rose from 1.3 (95% CI, 1.23-1.36) to 6.3 (95% CI, 6.12-6.40), with the sharpest increase from 2018 to 2021. Males experienced greater HHD mortality over the study period (increasing from 1.76 to 9.13 deaths per 100,000 person-years) than females (0.76-3.31 deaths per 100,000 person-years). Differences were also noted by race and ethnicity, with non-Hispanic Black individuals experiencing greater HHD mortality that non-Hispanic White and Hispanic individuals. Age-related and geographic differences were also observed. The proportionate HHD mortality increased from 3.8% in 1999 to 16.8% in 2024. Sustained increases in HHD mortality were observed after the COVID-19 pandemic relative to prepandemic levels. HHD-related mortality among young adults in the United States has risen significantly, with differences noted by sex, race and ethnicity, age, rural and urban residence, state, and Census region. The growing share of HHD deaths among CVD deaths in young adults signals its increasing role in premature CVD mortality. In conclusion, these trends underscore the urgent need for early prevention, equitable care, and targeted strategies to reduce HHD in young adults.
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Registered trials
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