ArticleJACC. Case reports2025
Metastatic Melanoma Presenting as Multiple Cardiac Masses: The Critical Role of Endomyocardial Biopsy.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
backgroundTachycardia-induced cardiomyopathy (TICM) is typically reversible with rhythm control, but individual susceptibility remains poorly understood and may reflect genetic predisposition. CASE SUMMARY: A 66-year-old woman with paroxysmal atrial fibrillation (AF) presented with new-onset heart failure. Genetic testing identified a likely pathogenic heterozygous ABCC9 gene variant (c.3892+2T>C), not previously associated with dilated cardiomyopathy or AF. ABCC9 loss-of-function mutations have been linked with cardiac channelopathies and cardiomyopathies. Ventricular function improved with rhythm control and medical therapy. DISCUSSION: This case illustrates the role of ABCC9 mutations in arrhythmia-induced cardiomyopathy beyond pure TICM. This variant has not been previously reported in individuals with this condition. The co-occurrence of prolonged QT interval, familial AF, and dilated cardiomyopathy underscores the value of genetics in cardiac disease. TAKE-HOME MESSAGES: Genetic testing may reveal causes in atypical cardiomyopathies and arrhythmias. This novel ABCC9 variant suggests a genetic contribution to AF-induced cardiomyopathy beyond the expected course of TICM.
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