Evidence map›Paper›PMID 41005952›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Pregnancy-dependent cardioprotection via GPER activation in Dahl salt-sensitive rats with superimposed preeclampsia.

Allan K N Alencar, Kenneth F Swan, Mistina M Manoharan, Christopher A Natale, Sarah H Lindsey, Gabriella C Pridjian, Michael R Garrett, Carolyn L Bayer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Allan K N AlencarDepartment of Biomedical Engineering, Tulane University, New Orleans, Louisiana, United States.ORCID 0000-0002-3072-6270
Kenneth F SwanDepartment of Obstetrics and Gynecology, Tulane University, New Orleans, Louisiana, United States.
Mistina M ManoharanDepartment of Biomedical Engineering, Tulane University, New Orleans, Louisiana, United States.ORCID 0009-0007-0292-5006
Christopher A NataleLinnaeus Therapeutics, Haddonfield, New Jersey, United States.
Sarah H LindseyDepartment of Pharmacology, Tulane University, New Orleans, Louisiana, United States.ORCID 0000-0002-9837-4582
Gabriella C PridjianDepartment of Obstetrics and Gynecology, Tulane University, New Orleans, Louisiana, United States.
Michael R GarrettDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0001-5234-7928
Carolyn L BayerDepartment of Biomedical Engineering, Tulane University, New Orleans, Louisiana, United States.ORCID 0000-0003-0947-6892

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Impact of hypertension and high-fat diet on mechanisms by which estradiol affects the hippocampal memory system.P01AG071746 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI Sarah Hoffmann Lindsey · 2022 to 2026
$17.1M
Sex differences in operant cocaine memoriesP20GM144041 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ramona Moles · 2023 to 2026
$12.1M
Eliciting Estrogen's Protective Vascular EffectsR01HL133619 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI LINDSEY, SARAH H. · 2017 to 2021
$2.2M
Genetic Targets of Hypertension End Organ DamageR01HL137673 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI GARRETT, MICHAEL R · 2018 to 2021
$1.6M
Placental Functional Imaging to Predict Preeclampsia Therapeutic OutcomesR01HD097466 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BAYER, CAROLYN LOUISE · 2019 to 2023
$1.6M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD097466HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL133619HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL137673HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM144041HHS | NIH | National Institute on Aging (NIA) AG071746Mississippi IDeA Network of Biomedical Research Excellence (MSINBRE) P20GM103476NHLBI NIH HHS R01 HL133619NHLBI NIH HHS R01 HL137673NIA NIH HHS P01 AG071746NICHD NIH HHS R01 HD097466NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P20 GM144041
6 · The paper itself

Abstract

Preeclampsia is a hypertensive disorder of pregnancy that affects multiple organs, increasing cardiovascular risks for both the mother and offspring. This study investigated LNS8801, a selective and orally bioavailable G protein-coupled estrogen receptor (GPER) agonist, to improve cardiac function in virgin and pregnant Dahl salt-sensitive (SS/Jr) rats, a model of superimposed preeclampsia with exacerbated cardiac and renal dysfunction during pregnancy. Female Dahl SS/Jr rats bred at 18-20 wk were randomized into four groups: Virgin + Vehicle, Virgin + LNS8801, Pregnant + Vehicle, and Pregnant + LNS8801. LNS8801 was orally administered in pregnant rats from

Indexed as

Cardiotonic AgentsPre-EclampsiaReceptors, EstrogenReceptors, G-Protein-CoupledVentricular Function, LeftAnimalsBlood PressureDisease Models, AnimalFemalePregnancyRatsRats, Inbred DahlCardiotonic AgentsGper1 protein, ratReceptors, EstrogenReceptors, G-Protein-Coupledcardiac dysfunctioncardiovascular diseaseG protein-coupled estrogen receptor (GPER)preeclampsiapregnancy

Identifiers

PMID41005952
PMCPMC12703943

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.