Evidence map›Paper›PMID 41006065›Full record

ArticleAmerican journal of physiology. Renal physiology2025

Diurnal function and expression of aquaporins in the mouse kidney.

Hung Nguyen, Nha Van Huynh, Kelly A Hyndman

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In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hung NguyenSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0009-0006-8659-7080
Nha Van HuynhSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-4328-0703
Kelly A HyndmanSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-8465-2588

Funding

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK128001NIDDK NIH HHS R01 DK128001NIDDK NIH HHS R03 DK120503UAB | Heersink School of Medicine, University of Alabama at Birmingham (UAB Medicine) intramural
6 · The paper itself

Abstract

Aquaporins (AQPs) are a family of water channels found throughout the body and in the kidney; they function in maintaining water homeostasis. The insertion of AQPs into the plasma membrane of the kidney cells drives water reabsorption back into the circulation, and the concentration of the urine involves AQP2 apical localization in the collecting duct principal cells. Kidney functions, like glomerular filtration rate (GFR) and urine flow, are significantly greater during the active period compared with the inactive period when sleeping. We hypothesized that there is a diurnal pattern in urine and/or plasma osmolality and that this reflects changes in kidney aquaporins in mice. Male and female C57BL/6J mice were studied in the middle of their active period [zeitgeber time (ZT) 18] or the middle of their inactive period (ZT6). We confirmed GFR was greater at ZT18 compared with ZT6. Urine and plasma osmolality were significantly greater at ZT18 in both sexes. Although ∼18% of kidney RNA had a diurnal pattern, the changes observed in the

Indexed as

AquaporinsCircadian RhythmKidneyAnimalsAquaporin 1Aquaporin 2Aquaporin 4FemaleGlomerular Filtration RateMaleMiceMice, Inbred C57BLOsmolar ConcentrationAqp1 protein, mouseAqp2 protein, mouseAqp4 protein, mouseAquaporin 1Aquaporin 2Aquaporin 4Aquaporinsaquaporin-2kidneyosmolalitysextime-of-day

Identifiers

PMID41006065
PMCPMC12767696

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.