ArticleThe oncologist2025
Validation of the FACIT-Fatigue scale in patients with locally advanced or metastatic breast cancer.
Article in The oncologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Article
- Health-related quality of life in palliative care: determinants identified in a hospital-based observational study.BMC palliative care · 2025Observational
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Authors and funding
8 authors.
Funding
Abstract
backgroundCancer-related fatigue (CRF) is a common symptom in patients with locally advanced or metastatic breast cancer (LA/M BC) receiving taxane-based chemotherapy (CT). CRF is commonly assessed as a subjective experience by patient questionnaires, such as the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue. The aim of this study was to extend the validity of the FACIT-Fatigue and estimate clinically meaningful group-level differences in this patient population. MATERIALS AND
methodsThis was a prospective, noninterventional, multinational study conducted in the United States and Italy from October 2021 to August 2023 in adult patients with LA/M BC eligible to receive cycle 1 of taxane-based CT. Patients completed a FACIT-Fatigue survey before starting CT and every 3 to 4 weeks for ∼16 weeks; a group of patients participated in a qualitative substudy to explore additional fatigue factors via semistructured, phone-based cognitive interviews.
resultsSixty-two female patients with a mean (standard deviation) age of 55.5 (12.2) years were included. Baseline (visit 1) mean (95% confidence interval) FACIT-Fatigue score was 39.0 (36.8, 41.2), and fatigue worsened over time from 36.6 at visit 2 to 31.9 at visit 5. All FACIT-Fatigue items were relevant, with patients frequently reporting physical and psychological fatigue during treatment; the most highly relevant items were "I feel listless" and "I have to limit my social activity because I am tired." Triangulation of anchor-based, distribution-based, and qualitative-based methods determined a meaningful group-level difference of 2.4 points.
conclusionThe FACIT-Fatigue survey includes items relevant to patients with LA/M BC on taxane-based CT.
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