Evidence map›Paper›PMID 41006234›Full record

ArticleNature communications2025

High expression of Rex-orf-I and HBZ mRNAs and bronchiectasis in lung of HTLV-1A/C infected macaques.

Sarkis Sarkis, Anna Gutowska, Mohammad Arif Rahman, Luca Schifanella, Katherine C Goldfarbmuren, Massimiliano Bissa, Ramona Moles, Christina Ramirez, Elijah F Edmondson, Andrew Warner and 12 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Sarkis SarkisAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. sarkis.sarkis@hotmail.com.ORCID http://orcid.org/0000-0002-4355-6338
Anna GutowskaAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9873-6432
Mohammad Arif RahmanAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6120-8943
Luca SchifanellaAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Katherine C GoldfarbmurenAdvanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0001-8774-7454
Massimiliano BissaAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3455-3992
Ramona MolesAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Christina RamirezMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Elijah F EdmondsonMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-6106-3705
Andrew WarnerMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0001-6023-1423
Melvin DosterAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Isabela Silva de CastroAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Robyn Washington-ParksAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Sophia BrownAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Joshua KramerLaboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Matthew W BreedMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Kristin E KilloranMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-5400-1231
Yogita JethmalaniVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Leonid SerebryannyyVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Damian Fj PurcellDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-4485-1726
Cynthia A Pise-MasisonAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Genoveffa FranchiniAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. franchig@mail.nih.gov.ORCID http://orcid.org/0000-0003-2851-6589

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HTLV-1 type-A rarely causes lung disease in humans, whereas HTLV-1 type-C is more frequently associated with respiratory failure and premature death. We investigated the genetic basis of HTLV-1C morbidity by constructing a chimeric HTLV-1A/C

Indexed as

Basic-Leucine Zipper Transcription FactorsBronchiectasisHTLV-I InfectionsHuman T-lymphotropic virus 1LungRetroviridae ProteinsRetroviridae Proteins, OncogenicAnimalsGene Expression Regulation, ViralHumansMacacaMacaca mulattaMaleMonocytesOpen Reading FramesRNA, MessengerBasic-Leucine Zipper Transcription FactorsHBZ protein, human T-cell leukemia virus type IRetroviridae ProteinsRetroviridae Proteins, OncogenicRNA, Messenger

Identifiers

PMID41006234
PMCPMC12474910

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.