Evidence mapPaperPMID 41006255Full record

ArticleNature communications2025

Schottky engineering of GDYO@Pt to boost piezoelectric and oxidative stress modulation for accelerated cranial regeneration.

Kang Song, Xuezheng Geng, Huan Yin, Yanzhu Shi, Jiawei Wang, Jiayu Yu, Mateng Bai, Lizhen Wang, Yurui Xue, Chunli Song and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kang SongMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.
Xuezheng GengMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.
Huan YinMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.
Yanzhu ShiMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.
Jiawei WangMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.
Jiayu YuMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.
Mateng BaiMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.
Lizhen WangMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China. lizhenwang@buaa.edu.cn.ORCID http://orcid.org/0000-0002-9658-659X
Yurui XueState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China. yrxue@jlu.edu.cn.ORCID http://orcid.org/0000-0002-9783-1753
Chunli SongDepartment of Orthopedics, Peking University Third Hospital, Beijing, China. schl@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-3690-9457
Yubo FanMedical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China. yubofan@buaa.edu.cn.ORCID http://orcid.org/0000-0002-3480-4395

Funding

National Natural Science Foundation of China (National Science Foundation of China) 12172034National Natural Science Foundation of China (National Science Foundation of China) 12332019National Natural Science Foundation of China (National Science Foundation of China) 12425209National Natural Science Foundation of China (National Science Foundation of China) T2288101Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) L232023
6 · The paper itself

Abstract

Piezoelectric stimulation regulates cellular metabolism and enhances bone repair. However, the overproduction of reactive oxygen species (ROS) and hypoxia-induced oxidative stress reduce the efficacy of electrical stimulation and hinder regeneration. Here, a platinum-decorated graphdiyne oxide (GDYO@Pt) multifunctional piezoelectric semiconductor was engineered to eliminate ROS and oxygen self-supply while enabling electrical stimulation. In this system, the interface dipole drives a built-in electric field, triggering charge redistribution in GDYO and breaking symmetry to amplify piezoelectricity. Ultrasound-triggered polarized charges at the Schottky junction lower the barrier and promote GDYO→Pt electron transfer for hydrogen production, where the generated H

Indexed as

Bone RegenerationGadoliniumGraphiteOxidative StressPlatinumSkullAnimalsElectric StimulationHumansHydrogen PeroxideMaleMiceOsteogenesisReactive Oxygen SpeciesSemiconductorsGadoliniumGraphiteHydrogen PeroxidePlatinumReactive Oxygen Species

Identifiers

PMID41006255
PMCPMC12475170

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.