Evidence map›Paper›PMID 41006292›Full record

ArticleNature communications2025

Aging in mice alters regionally enriched striatal astrocytes.

Kay E Linker, Violeta Duran-Laforet, Matthias Ollivier, Xinzhu Yu, Dorothy P Schafer, Baljit S Khakh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kay E LinkerDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. kaylinker@gmail.com.ORCID http://orcid.org/0000-0002-8825-6187
Violeta Duran-LaforetDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Matthias OllivierDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Xinzhu YuDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1244-0110
Dorothy P SchaferDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Baljit S KhakhDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. bkhakh@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-0939-1218

Funding

How Do Synaptic Connections Change in Demyelinating Disease?R01NS117533 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2022 to 2025
$1.3M
Fundamental astrocyte biology in intact neural circuitsR35NS111583 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$1.0M
Microglia-Astrocyte Crosstalk Regulating SynapseRemodelingR01MH113743 · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2025 to 2025
$541k
BrightFocus Foundation (BrightFocus) A2022006FNIA NIH HHS R01 AG068281NIA NIH HHS RF1 AG068281NIDA NIH HHS R01 DA047444NIMH NIH HHS F32 MH125598NIMH NIH HHS R01 MH113743NINDS NIH HHS R01 NS117533NINDS NIH HHS R35 NS111583U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F32MH125598U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH113743U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS111583U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS117533U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA047444
6 · The paper itself

Abstract

Aging affects multiple organs and within the brain drives distinct molecular changes across different cell types. The striatum encodes motor behaviors that decline with age, but our understanding of how cells within the striatum change remains incomplete. Using single-cell RNA sequencing from young and aged mice we identify molecularly distinct astrocyte subtypes. We show that astrocytes change significantly with age, exhibiting downregulation of genes, reduced diversity, and a shift to more homogenous inflammatory transcriptomic profiles. By exploring where striatal astrocyte subtypes are located with single-cell resolution, we map astrocytes enriched in dorsal, medial, and ventral striatum. Age increases inflammatory marker transcripts in dorsal striatal astrocytes, which display greater age-related changes than ventral striatal astrocytes. We impute molecular interactions between astrocytes and neurons and find that age particularly reduced interactions related to Nrxn2. Our data show that aging alters regionally enriched striatal astrocytes asymmetrically, with dorsal striatal astrocytes exhibiting greater age-related molecular changes.

Indexed as

AgingAstrocytesCorpus StriatumAnimalsFemaleMaleMiceMice, Inbred C57BLNeuronsSingle-Cell AnalysisTranscriptome

Identifiers

PMID41006292
PMCPMC12475473

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.