Evidence map›Paper›PMID 41006317›Full record

ArticleNPJ Parkinson's disease2025

N-type Ca

Emmanouela Leandrou, Ioanna Chalatsa, Kostas Vekrellis, Evangelia Emmanouilidou

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emmanouela LeandrouDepartment of Chemistry, School of Sciences, National and Kapodistrian University of Athens; Panepistimioupolis Zografou, Athens, 15772, Greece.
Ioanna ChalatsaDepartment of Chemistry, School of Sciences, National and Kapodistrian University of Athens; Panepistimioupolis Zografou, Athens, 15772, Greece.
Kostas VekrellisCenter for Basic Research, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, 11527, Greece.
Evangelia EmmanouilidouDepartment of Chemistry, School of Sciences, National and Kapodistrian University of Athens; Panepistimioupolis Zografou, Athens, 15772, Greece. eemman@chem.uoa.gr.

Funding

Hellenic Foundation for Research and Innovation 581Michael J. Fox Foundation for Parkinson's Research 15655
6 · The paper itself

Abstract

The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α-synuclein release in vivo in the presence of selective channel inhibitors. Our results revealed that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum.

Identifiers

PMID41006317
PMCPMC12475288

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.