ArticleScientific reports2025
Long term monitoring shows phase lagged behaviorally driven locomotor autonomic coupling.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Control vs. salience: a new axis of circadian brain-body organization.Npj biological timing and sleep · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
The temporal coordination between behavioral and autonomic rhythms is a critical feature of circadian physiology, yet the precise alignment and causal structure of this coupling remain poorly characterized in free-living humans. Using long-term wearable data spanning 30 days from 52 individuals, we analyzed accelerometry (ACC) and heart rate (BPM, via IBI) to quantify circadian phase alignment, inter-day stability, and temporal directionality between locomotor and autonomic systems. Across individuals, behavioral activity rhythms consistently peaked earlier than autonomic rhythms (mean lag: -1.8h, p < 0.001), with the lag largely attributable to greater variability in locomotor phase. Despite this temporal dissociation, both signals exhibited coherent 24-h patterns and relatively stable inter-day acrophases. Lag magnitude was negatively correlated with nighttime BPM (r = -0.55, p < 0.001), suggesting a link between autonomic hyperactivation and desynchrony. Crucially, behavioral acrophase more strongly predicted daily lag fluctuations than BPM acrophase, and causal analyses revealed asymmetric dependencies: same-day activity levels were significantly predictive of nighttime heart rate, whereas the reverse relationship was weaker and less consistent. Granger causality confirmed: a predominant flow from ACC to BPM across subjects (p = 0.0045). These findings establish that autonomic rhythms lag behind and are shaped by preceding behavioral activation, supporting a behavior-first model of internal circadian organization.
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Registered trials
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