ArticleScientific reports2025
Lanthanum exposure and its metabolomic effects on Ruditapes philippinarum.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Enhanced Untargeted Metabolomics Based on High-Resolution Mass Spectrometry Reveals Global Rewiring Due to Mitochondrial Dysfunction in Yeast.International journal of molecular sciences · 2026Article
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8 authors.
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Abstract
The growing release of rare earth elements (REEs) into aquatic environments, driven by their extensive industrial and technological applications, has raised growing concern due to their largely unknown ecological and toxicological effects. Among these, lanthanum (La), one of the most widely used REEs, is increasingly detected in marine ecosystems. This study investigates the short-term impact of exposure on the Manila clam, Ruditapes philippinarum, a key benthic species in Mediterranean aquaculture. Clams were exposed to 10 mg/L of LaCl₃·7 H₂O, and their gill tissues were analyzed through histological examination and untargeted metabolomics. Histological analysis revealed epithelial degeneration, decreased mucus secretion, and altered glycoprotein expression following exposure. Metabolomic profiling identified 188 differentially expressed metabolites (DEMs) associated with disruptions in organic acid, fatty acid, amino acid, and nucleotide metabolism. Functional analysis of DEMs revealed that alterations in glutathione (GSH), ascorbic acid, oleic acid, and thymidine levels may serve as biomarkers of La-induced oxidative and metabolic stress in bivalves. These findings emphasize the ecological threats associated with the increasing REEs contamination in marine environments.
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