ArticleScientific reports2025
Antinuclear antibodies in early multiple sclerosis reflect systemic lupus erythematosus shared risk factors.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
After a clinically isolated syndrome (CIS), antinuclear antibodies (ANAs) are often measured in diagnostic workup of inflammatory diseases. Although ANAs are associated with systemic lupus erythematosus (SLE), increased prevalence has been observed in multiple sclerosis (MS) with controversial significance. We determined in a prospective cohort study the association of ANAs measured during diagnostic workup with shared MS and SLE risk factors, clinical characteristics and disease course in CIS patients aged 18-65 years. ANA positivity was found in 60/364 (16.5%) participants and associated with female sex (83.3% vs. 67.4%, p = 0.01) and higher anti-EBNA1 IgG titres (median 1450.0 vs. 588.0 U/ml, p < 0.01), compared to ANA-negative participants. ANA-positive participants were more often homozygous carriers of HLA-DRB1*15:01 (12.8% vs. 2.7%, p < 0.01), but did not show higher MS or SLE genetic risk. Clinical characteristics and early disease course, estimated with Cox regression, were similar between participants with or without ANAs, regardless of a subsequent MS diagnosis. This study helps clinicians better interpret ANA positivity in patients with CIS. Our data demonstrate that ANA positivity during diagnostic workup for MS does not indicate a different disease course, but may reflect shared genetic and environmental risk factors for MS and SLE. Further studies should explore shared disease mechanisms.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.