ArticleScientific reports2025
7T MRI and histology reveal early tissue and perfusion changes after radiofrequency ablation in a murine colorectal cancer model.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Considering neo-angiogenesis as one of the most important hallmarks of solid tumors and a key promoter of recurrence, perfusion studies represent a modality to investigate tumor's vascularization and to identify its influence on chemotherapy efficacy. To analyze neoplastic tissue adjacent to radiofrequency thermal-ablation (RFA) areas to demonstrate early perfusion anomalies and to suggest the synergic role of ablative techniques with chemotherapy treatments. In this prospective study, a total of 10 mice were subjected to a colon-carcinoma cell implantation and after the tumor colonization the RFA procedure was performed. All mice underwent a 7T MRI including 2D single-echo single-shot Dynamic-Contrast-Enhanced (DCE) sequences with intravenous injection of Gadolinium-based contrast agent (CA), before and after 72 h from RFA treatment. Data-driven segmentation of the tumor mass enabled the identification of three ROIs with peculiar pharmacokinetic profiles of CA uptake: VTA, viable tumor area; PNA, partial necrotic area; CNA, complete necrotic area. Within these ROIs, permeability (K-trans and Extravascular-extracellular volume, Ve) and perfusion (Time to Peak, TTP) indices were evaluated with non-parametric paired samples Wilcoxon tests. Robust increase of Ve (PNA and VTA, p = 0.014, p < 0.001, respectively) and TTP (VTA, p < 0.01) is consistent with severe cellular and vascular damage induced by RFA. Perfusion MRI enables robust detection of significant modulation of the microvasculature within 72 h from radiofrequency induced ablation in a murine model of colon-carcinoma. This opens a potentially new time window for the evaluation of therapeutic effects of RFA-enhanced chemotherapy.
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