ArticleScientific reports2025
Shared immune biomarkers in necrotizing enterocolitis and neonatal sepsis identified via bioinformatics and machine learning.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial intelligence in pediatric intensive care units: current applications in sepsis management.World journal of pediatrics : WJP · 2026Pooled it
- Clinical impact of early-onset sepsis on outcomes of necrotizing enterocolitis: a retrospective case-control study.BMC pregnancy and childbirth · 2026Article
- The immune dysregulation landscape and dynamic regulation of competing endogenous RNAs in spinal cord injury.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Necrotizing enterocolitis (NEC) and neonatal sepsis (NS) are major causes of morbidity and mortality in preterm infants, yet their shared molecular basis remains poorly defined. In this study, we integrated two public transcriptomic datasets and applied differential expression analysis, weighted gene co-expression network analysis (WGCNA), and three machine learning algorithms (LASSO, random forest, and XGBoost) to identify shared biomarkers. Four immune-related biomarkers (MAP2K6, CHKA, CA4, and ENTPD7) were identified and used to construct diagnostic models with high performance (AUC = 0.864 for NS; 1.000 for NEC). Immune infiltration analysis revealed distinct immune cell signatures and strong correlations with the selected biomarkers. Regulatory network construction further uncovered potential transcriptional and post-transcriptional regulatory mechanisms. These findings suggest a common immune-related pathogenesis underlying NEC and NS and highlight shared biomarkers with strong diagnostic potential. This integrative analysis provides a foundation for improved early diagnosis and targeted interventions in neonatal care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.