Evidence map›Paper›PMID 41006492›Full record

ArticleScientific reports2025

Intramuscular enteric glia persist in Hirschsprung disease and undergo neurogenesis in response to GDNF-NCAM1 signaling.

Jessica L Mueller, Chris Han, Abigail Leavitt, Vipin Chauhan, Leah Ott, Richard A Guyer, Toshihiro Uesaka, Hideki Enomoto, Lily Cheng, Ryo Hotta and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jessica L MuellerDepartment of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Chris HanDepartment of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Abigail LeavittDepartment of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Vipin ChauhanDepartment of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Leah OttDepartment of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Richard A GuyerDepartment of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Toshihiro UesakaDepartment of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Hideki EnomotoDepartment of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Lily ChengDepartment of Pediatric Surgery, University of Virginia, Charlottesville, VA, 22908, USA.
Ryo HottaDepartment of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Alan J BurnsDepartment of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Rhian Stavely *Department of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA.
Allan M Goldstein *Department of Pediatric Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Warren 1151, Boston, MA, 02114, USA. amgoldstein@mgb.org.

Funding

Characterizing neurogenic progenitors in the adult intestineR01DK119210 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ALLAN M GOLDSTEIN · 2020 to 2026
$2.5M
Investigating the role of biomechanical forces on the enteric nervous system in Hirschsprung diseaseK08DK133673 · NIDDK · UNIVERSITY OF VIRGINIA · PI Lily S Cheng · 2022 to 2026
$830k
Uncovering the therapeutic potential of adipose tissue derived neural stem cells for Hirschsprung's disease.R21HD106036 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI GOLDSTEIN, ALLAN M, STAVELY, RHIAN · 2022 to 2023
$452k
Modifying the intestinal extracellular matrix to optimize enteric neuronal stem cell therapy for Hirschsprung diseaseF32DK131792 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MUELLER, JESSICA · 2022 to 2023
$160k
National Institute of Child Health and Human Development R21HD106036NICHD NIH HHS R21 HD106036NIDDK NIH HHS 5R01DK119210NIDDK NIH HHS F32 DK131792NIDDK NIH HHS F32DK131792NIDDK NIH HHS K08 DK133673NIDDK NIH HHS R01 DK119210
6 · The paper itself

Abstract

Hirschsprung disease (HSCR) is a neurocristopathy, yet paradoxically, neural crest-derived EGCs are present within the muscle of the affected region. This study investigates the molecular identity, origins, and neurogenic potential of EGCs in the aganglionic mouse and human colon. We utilized single-cell RNA sequencing (scRNA-seq), immunohistochemistry, and in vitro culture of EGCs from aganglionic and ganglionated segments of Ednrb-null mice (Plp1-GFP;Baf-tdT;Ednrb

Indexed as

CD56 AntigenGlial Cell Line-Derived Neurotrophic FactorHirschsprung DiseaseNeurogenesisNeurogliaAnimalsColonEnteric Nervous SystemHumansMaleMiceMice, KnockoutNeural CrestReceptor, Endothelin BSignal TransductionCD56 AntigenEDNRB protein, mouseGDNF protein, humanGdnf protein, mouseGlial Cell Line-Derived Neurotrophic FactorNCAM1 protein, humanReceptor, Endothelin BEnteric glial cellsGDNF signalingHirschsprung diseaseNeurogenesis

Identifiers

PMID41006492
PMCPMC12474993

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.