Evidence map›Paper›PMID 41006797›Full record

ArticleScientific reports2025

In silico approaches unveil the mechanism of action of Eclipta prostrata against acute myeloid leukemia.

K M Tanjida Islam, Md Muzahidul Islam, Jisan Bin Habib, Susen Sarker, Azrin Ahmed, Md Sohel, Fahmida Tabassum, Saborni Sarker, Sheikh Abdullah Al Ashik, Roksana Khanam and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Phytochemical Characterization ofFood science & nutrition · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

K M Tanjida IslamDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Md Muzahidul IslamDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Jisan Bin HabibDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Susen SarkerDepartment of Biochemistry and Molecular Biology, Jagannath University, Dhaka, 1100, Bangladesh.
Azrin AhmedDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Md SohelDepartment of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Fahmida TabassumDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Saborni SarkerDepartment of Biotechnology, Faculty of Agriculture, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh.
Sheikh Abdullah Al AshikDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Roksana KhanamDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Shahin MahmudDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh. shahin018mbstu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a poor prognosis. While the medicinal plant Eclipta prostrata has shown promising anticancer properties against AML, its underlying mechanisms against AML remain largely unexplored. Hence, this study aimed to unveil the molecular mechanisms of E. prostrata, identify therapeutic targets, detect regulatory elements, and discover potential biomarkers for AML using comprehensive in-silico analyses. We implemented an integrated computational approach combining network pharmacology, molecular docking, molecular dynamics simulations, 3D-QSAR modeling, gene regulatory network, gene expression, patient survival, and cancer hallmarks analysis to investigate the mechanism of action of E. prostrata against AML. Our computational approaches identified 12 potential anti-cancer compounds from E. prostrata. Molecular docking revealed strong binding affinities of Kaempferol (-8.931 kcal/mol) and Apigenin (-8.752 kcal/mol) to FLT3, compared to control Pacritinib (-5.403 kcal/mol). Tricetin (-8.634 kcal/mol) and Diosmetin (-7.780 kcal/mol) showed strong binding to PIM1 compared to control SEL24 (-6.385 kcal/mol). Post-molecular dynamics simulation MM-GBSA analysis further confirmed these interactions, with binding free energies for FLT3: Kaempferol (-73.75 kcal/mol), Apigenin (-68.76 kcal/mol), Pacritinib (-51.27 kcal/mol); and for PIM1: Tricetin (-64.28 kcal/mol), Diosmetin (-52.2 kcal/mol), SEL24 (-53.38 kcal/mol). Predicted IC

Indexed as

Antineoplastic Agents, PhytogenicEcliptaLeukemia, Myeloid, AcutePlant ExtractsComputer Simulationfms-Like Tyrosine Kinase 3Gene Regulatory NetworksHumansMolecular Docking SimulationMolecular Dynamics SimulationQuantitative Structure-Activity RelationshipAntineoplastic Agents, PhytogenicFLT3 protein, humanfms-Like Tyrosine Kinase 3Plant Extracts3D-QSARAcute myeloid leukemia (AML)BiomarkersEclipta prostrataMechanism of actionMolecular dynamics simulationTherapeutic targets

Identifiers

PMID41006797
PMCPMC12474914

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.