Evidence map›Paper›PMID 41006815›Full record

SynthesisObesity surgery2025

Transoral Outlet Reduction for Dumping Syndrome After Roux-En-Y Gastric Bypass: a Comprehensive Systematic Review and Meta-Analysis.

Azizullah Beran, Daryl Ramai, Almaza Albakri, Khaled Alchirazi, Nasir Saleem, Mark A Gromski

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Azizullah BeranDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA. aziz@iu.edu.
Daryl RamaiGastroenterology, Brigham and Women's Hospital, Boston, MA, USA.
Almaza AlbakriInternal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Khaled AlchiraziGastroenterology, Aurora St. Luke's Medical Center, Milwaukee, MI, USA.
Nasir SaleemDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.
Mark A GromskiDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDumping syndrome is a complication of Roux-en-Y gastric bypass (RYGB) surgery that can significantly affect quality of life. Transoral outlet reduction (TORe) is a minimally invasive endoscopic procedure that reduces the size of the gastrojejunal anastomosis (GJA) through ablation and/or endoscopic suturing, primarily used to address weight regain after RYGB. Emerging evidence highlights the feasibility and safety of TORe as a treatment for medically refractory dumping syndrome. This meta-analysis aims to evaluate the efficacy and safety of TORe for dumping syndrome.

methodsA systematic search of PubMed, Embase, and Web of Science was conducted through December 2024. Primary outcomes included clinical success (defined as sustained symptom improvement without requiring repeat TORe or revisional surgery at last follow-up) and the mean difference in pre- and post-procedural Sigstad's score assessments. Secondary outcomes included rates of post-TORe surgery, repeat TORe, and serious adverse events. Pooled rate estimates and mean differences (MD) with the corresponding 95% confidence intervals (CI) were calculated using random-effects models.

resultsSix studies with 333 post-RYGB patients with dumping syndrome were included. The pooled clinical success of TORe was 83% (95% CI 71%-90%, I

conclusionsOur findings suggest that TORe is a safe and effective minimally invasive treatment for patients with medically refractory dumping syndrome. Further prospective studies with longer follow-up durations are warranted to validate these findings.

Indexed as

Dumping SyndromeGastric BypassNatural Orifice Endoscopic SurgeryPostoperative ComplicationsHumansObesity, MorbidTreatment OutcomeDumping syndromeGastrojejunal anastomosis revisionRoux-en-Y gastric bypassTransoral outlet reduction

Identifiers

PMID41006815
PMCPMC12594707

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.