Evidence map›Paper›PMID 41007290›Full record

ArticleBiology2025

Mutational Analysis Reveals Functional Roles of METTL16 Domains and Residues.

Kurtis Breger, Ian P Schowe, Noah A Springer, Nathan J O'Leary, Agnieszka Ruszkowska, Carlos Resende, Jessica A Brown

Abstract read
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kurtis BregerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Ian P SchoweDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0009-0000-1021-1547
Noah A SpringerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0001-8868-0415
Nathan J O'LearyDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0001-7200-499X
Agnieszka RuszkowskaDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0002-9862-4406
Carlos ResendeDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0002-3639-182X
Jessica A BrownDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0001-9055-5939

Funding

Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
Characterization of a Model System to Advance Triple-Stranded RNA BiologyR35GM133696 · NIGMS · UNIVERSITY OF NOTRE DAME · PI BROWN, JESSICA ANN · 2019 to 2023
$1.9M
Elucidating the Inhibitory Mechanisms of RNA Triple Helices in Nuclear DecayR00GM111430 · NIGMS · UNIVERSITY OF NOTRE DAME · PI BROWN, JESSICA ANN · 2016 to 2018
$743k
Chemistry-Biochemistry-Biology Interface Program T32GM075762Henry Luce Foundation Clare Boothe Luce Assistant ProfessorshipNIGMS NIH HHS R00 GM111430NIGMS NIH HHS R35 GM133696NIGMS NIH HHS T32 GM075762NIH HHS 1R00GM111430-03NIH HHS 1R35GM133696-03University of Notre Dame College of Science Summer Undergraduate Research Fellowship Program
6 · The paper itself

Abstract

Human methyltransferase-like protein 16 (METTL16) installs

Indexed as

methyltransferaseMETTL16N6-methyladenosineU6 snRNA

Identifiers

PMID41007290
PMCPMC12467241

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.