Evidence map›Paper›PMID 41007305›Full record

ReviewBiology2025

Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture.

Nguyen Dinh-Hung, Luu Tang Phuc Khang, Suwanna Wisetkaeo, Ngoc Tuan Tran, Lee Po-Tsang, Christopher L Brown, Papungkorn Sangsawad, Sefti Heza Dwinanti, Patima Permpoonpattana, Nguyen Vu Linh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Unlocking the Potential ofFoods (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Unraveling the Effects ofInternational journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nguyen Dinh-HungAquaculture Pathology Laboratory, School of Animal & Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0001-5318-6265
Luu Tang Phuc KhangAquatic Biotechnology Laboratory, Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-8594-5083
Suwanna WisetkaeoAquatic Biotechnology Laboratory, Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand.
Ngoc Tuan TranInstitute of Marine Sciences, Shantou University, Shantou 515063, China.ORCID 0000-0003-1847-7301
Lee Po-TsangDepartment of Aquaculture, National Taiwan Ocean University, Keelung 202, Taiwan.ORCID 0000-0003-3657-2599
Christopher L BrownFAO World Fisheries University Pilot Programme, Pukyong National University, Busan 47340, Republic of Korea.ORCID 0000-0002-4578-3593
Papungkorn SangsawadSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.ORCID 0000-0003-2420-8634
Sefti Heza DwinantiDepartment of Aquaculture, Faculty of Agriculture, Sriwijaya University, Inderalaya 30662, Indonesia.ORCID 0000-0003-1126-5496
Patima PermpoonpattanaDepartment of Agricultural Science and Technology, Faculty of Innovative Agriculture, Fisheries and Food, Prince of Songkla University, Surat Thani Campus, Surat Thani 84000, Thailand.ORCID 0000-0002-0320-7184
Nguyen Vu LinhAquatic Biotechnology Laboratory, Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-0812-4764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caffeic acid (CA), a plant-derived phenolic compound, is emerging as a promising natural feed additive for sustainable aquaculture. Its growth-promoting, immunomodulatory, and antimicrobial activities suggest utility as an alternative that diminishes antibiotic use in fish farming. Evidence across multiple species indicates improvements in innate immune responses, enhanced antioxidant capacity, and increased survival during pathogen challenge. Nevertheless, adoption remains limited by unresolved questions regarding optimal inclusion levels, species-specific physiological responses, interactions with other dietary components, and effects on the gut microbiota. This review synthesizes current research on CA, critically evaluates its functional roles in aquaculture, and assesses its relevance to sustainable production. Priorities for future work include elucidating mechanisms of action, conducting cross-species dose-response studies, standardizing dosing protocols, clarifying microbiome effects, and evaluating economic feasibility for large-scale use. Addressing these gaps will be essential to realize the full potential of CA as a functional feed additive in sustainable aquaculture systems.

Indexed as

aquafeed additivesdisease resistanceimmunomodulatoryphyto-additivessustainable aquaculture

Identifiers

PMID41007305
PMCPMC12467778

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.