Evidence map›Paper›PMID 41007334›Full record

ArticleBiology2025

Quantification of Genes and Proteins Associated with Endothelial Cell Function After Different Exercise-Induced Shear Stress Intensities In Vitro.

Daniel Conde, Manuel Gomez, Alvaro N Gurovich

Abstract read
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel CondeClinical Applied Physiology (CAPh) Lab, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0009-0003-4481-6386
Manuel GomezClinical Applied Physiology (CAPh) Lab, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0009-0002-1856-9361
Alvaro N GurovichClinical Applied Physiology (CAPh) Lab, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0001-8823-3391

Funding

Synthetic 3D Model of the Carotid Artery to Study Exercise-Induced Changes in Endothelial Gene ExpressionSC2GM140952 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI GUROVICH, ALVARO N · 2021 to 2023
$681k
NIGMS NIH HHS SC2 GM140952
6 · The paper itself

Abstract

Cell culture models are used in cardiovascular research to study molecular pathways associated with endothelial shear stress (ESS). However, previous studies have limited translation from in vivo ESS, especially across exercise intensities. Using the Ibidi pump system, ESS can be replicated in vitro to study exercise-induced changes in protein and gene expression. Currently, there are no standardized protocols describing how to translate exercise-induced ESS from in vivo data to in vitro models. This protocol addresses that gap by integrating human exercise data to generate physiologically relevant ESS from 18 to 60 dyn/cm

Indexed as

exercise-induced shear stressHUVECimmunocytochemistryRT-PCRWestern blot

Identifiers

PMID41007334
PMCPMC12466968

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.