ReviewBiomedicines2025
Cardiac Endocrine Function and Hormonal Interplay in Pediatrics: From Development to Clinical Implications.
Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endocrine system plays a pivotal role in all stages of cardiac development and in maintaining the structural and functional integrity of the heart. Notably, the heart itself functions as an endocrine organ, producing hormones that regulate blood pressure, fluid balance, and myocardial remodeling. This narrative review explores the endocrine mechanisms underlying cardiac development and function, with a focus on fetal and pediatric life. Special attention is given to the heart's intrinsic endocrine activity and how hormonal signals interact with the cardiovascular system during early development. Hormonal signaling is essential for maintaining physiological homeostasis and supporting proper heart development during growth. Disruptions in these signals may serve as silent precursors to structural or functional heart disease, potentially manifesting later in life. Understanding these interactions is clinically relevant, as endocrine imbalances can contribute to the onset, progression, and prognosis of pediatric cardiac disorders. Early identification of hormonal dysregulation can help prevent or mitigate adverse cardiovascular outcomes. Furthermore, recognizing age-specific patterns in hormone-heart interactions may enable the development of targeted diagnostic and therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.