ArticleAnimals : an open access journal from MDPI2025
Ferulic Acid Alleviates Intestinal Inflammatory Damage in Mice, Associated with Ameliorating Intestinal Barrier Damage and Gut Microbiota.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Effects of dietary zinc fulvate supplementation on egg quality, serum biochemical indices, and intestinal health of aged laying hens.AMB Express · 2026Article
- Preventive effect of ferulic acid on dextran sulfate sodium-induced ulcerative colitis in mice.Frontiers in microbiology · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Intestinal inflammation remains one of the most common and severely harmful diseases in intensive farming systems. Ferulic acid (FA) has significant anti-inflammatory properties, but its role in intestinal inflammatory damage remains unclear. The aim of this study is to investigate the protective effect of FA (20, 40, 80 mg/kg) on lipopolysaccharide (LPS)-induced intestinal inflammatory damage in mice and its possible mechanism. FA treatment significantly reduced serum DAO and D-LA levels and suppressed intestinal expression of IL-1β, IL-6, and TNF-α. FA enhanced intestinal antioxidant activity by increasing GSH, SOD, and CAT levels, while reducing MDA concentrations. FA can increase the content of MUC-2 and promote the secretion of sIgA. The results of 16s rRNA gene sequencing revealed that FA regulated gut microbiota disorders associated with inflammation and mucosal barrier. The present study demonstrates that FA can alleviate LPS-induced intestinal inflammatory damage in mice by inhibiting inflammation, enhancing intestinal barrier function, and regulating the intestinal flora balance.
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Registered trials
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