Evidence mapPaperPMID 41008273Full record

ArticleBrain sciences2025

Combination Lorcaserin and Betahistine Treatment Improves Cognitive Dysfunction and Dopaminergic Neuron Activity in a Rat Model of Diet-Induced Obesity.

Ike de la Peña, Johnny Figueroa, Wei-Xing Shi

Abstract read
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ike de la PeñaDepartment of Pharmaceutical and Administrative Sciences, Loma Linda University School of Pharmacy, Loma Linda, CA 92350, USA.ORCID 0000-0003-2046-522X
Johnny FigueroaCenter for Health Disparities and Molecular Medicine, Department of Basic Sciences, Physiology Division, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.ORCID 0000-0003-4769-8736
Wei-Xing ShiDepartment of Pharmaceutical and Administrative Sciences, Loma Linda University School of Pharmacy, Loma Linda, CA 92350, USA.

Funding

LLU-NIH MINORITY STUDENT DEVELOPMENT PROGRAMR25GM060507 · NIGMS · LOMA LINDA UNIVERSITY · PI Marino De Leon · 2001 to 2022
$2.9M
NEUROPATHOLOGICAL SIGNATURES CONNECTING EARLY-LIFE TRAUMA TO COMPULSIVE EATING BEHAVIOR AND OBESITYR21DK124727 · NIDDK · LOMA LINDA UNIVERSITY · PI Johnny Davis Figueroa · 2022 to 2022
$197k
American Association of Colleges of Pharmacy (AACP) New Investigator Grant N/ALoma Linda University GRASP N/ANIDDK NIH HHS R21 DK124727NIGMS NIH HHS R25 GM060507NIH HHS DK124727NIH HHS GM060507NIH HHS MD006988NIMHD NIH HHS P20 MD006988
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

betahistinecognitioncombination treatmentlorcaserinobesityprefrontal cortex

Identifiers

PMID41008273
PMCPMC12467822

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.