Evidence map›Paper›PMID 41008310›Full record

ArticleBrain sciences2025

Investigating

Annika Bender, Laila Bertele, Mirac Nur Musaoglu, Sarah Pasche, Susanne Edelmann, Vanessa Nieratschker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Annika BenderDepartment of Psychiatry and Psychotherapy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.
Laila BerteleDepartment of Psychiatry and Psychotherapy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.
Mirac Nur MusaogluDepartment of Psychiatry and Psychotherapy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0002-7298-9909
Sarah PascheDepartment of Psychiatry and Psychotherapy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.ORCID 0009-0006-5203-2102
Susanne EdelmannDepartment of Psychiatry and Psychotherapy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.
Vanessa NieratschkerDepartment of Psychiatry and Psychotherapy, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0001-7884-4500

Funding

German Federal Ministry of Education and Research; German Center for Mental Health 01EE2306BGerman Research Foundation NI 1332/16-1German Research Foundation; International Research Training Group IRTG2804NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation 23494
6 · The paper itself

Abstract

backgroundBorderline Personality Disorder (BPD) is a complex psychiatric condition with multifactorial origins, with a high proportion of patients reporting early trauma. Stressors such as adverse childhood experiences (ACEs) can shape the epigenetic landscape including DNA methylation (DNAm) and act on gene expression. DNAm is increasingly being investigated as a molecular link between environmental exposures such as ACE and psychiatric outcomes. Differential DNAm of the gene PR domain zinc finger protein 8 (

methodsThis study investigated DNAm patterns of

resultsAt baseline, BPD patients demonstrated significant hypomethylation of

conclusionsOur findings suggest that

Indexed as

adverse childhood experiencesborderline personality disorderdialectic behavioral therapyDNA methylationPRDM8

Identifiers

PMID41008310
PMCPMC12467729

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.