Evidence map›Paper›PMID 41008535›Full record

ReviewBiomolecules2025

Transmembrane Protein 97 (TMEM97): Molecular Target and Treatment in Age-Related Macular Degeneration (AMD).

Alyssa Stathopoulos, Joshua J Wang, Stephen F Martin, Sarah X Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alyssa StathopoulosDepartment of Ophthalmology, Ira G. and Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY 14203, USA.
Joshua J WangDepartment of Ophthalmology, Ira G. and Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY 14203, USA.
Stephen F MartinDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-4639-0695
Sarah X ZhangDepartment of Ophthalmology, Ira G. and Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY 14203, USA.

Funding

Molecular Mechanisms of Severe Diabetic RetinopathyR01EY030970 · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2025 to 2025
$472k
Role of Intrinsic Neuroprotective Signaling in Diabetic RetinaR01EY036132 · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2025 to 2025
$441k
Nuclear encoded Humanin Isoforms and Mitochondria in Age-related Macular DegenerationR21EY035810 · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2025 to 2025
$241k
NEI NIH HHS R01 EY019949NEI NIH HHS R01 EY030970NEI NIH HHS R01 EY036132NEI NIH HHS R21 EY035810NIH/NEI EY019949, EY030970, EY035810, and EY036132
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a common eye disease that significantly affects daily activities and impedes the quality of life in aging adults, yet effective treatments to halt or reverse disease progression are currently lacking. Ongoing research aims at understanding the complex mechanisms underlying AMD pathophysiology involving retinal pigment epithelium (RPE) dysfunction, drusen formation, inflammation, neovascularization, and RPE/photoreceptor degeneration. Sigma 2 receptor/transmembrane protein 97 (σ

Indexed as

Macular DegenerationMembrane ProteinsReceptors, sigmaAnimalsHumansMolecular Targeted TherapyOxidative StressRetinal Pigment EpitheliumMembrane ProteinsReceptors, sigmamolecular target and treatmentretinal degenerationsmall moleculetransmembrane protein 97

Identifiers

PMID41008535
PMCPMC12467532

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.