Evidence map›Paper›PMID 41008565›Full record

ArticleBiomolecules2025

A Multi-Ingredient Supplement Improves Body Re-Composition, Ovarian Aging Markers, and Reproductive Success in Young and Middle-Aged Female Mice.

Alessandra Chiarot, Mahek Minhas, Nicoletta M de Maat, Jenny Doan, Mats I Nilsson, Bart P Hettinga, Mehrnoosh Faghih, Michael S Neal, Joshua P Nederveen, Mark A Tarnopolsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandra ChiarotDepartment of Pediatrics, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.
Mahek MinhasDepartment of Pediatrics, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.
Nicoletta M de MaatDepartment of Pediatrics, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.
Jenny DoanDepartment of Pediatrics, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.
Mats I NilssonExerkine Corporation, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.ORCID 0000-0001-5656-5578
Bart P HettingaExerkine Corporation, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.
Mehrnoosh FaghihDepartment of Obstetrics and Gynecology, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.
Michael S NealDepartment of Obstetrics and Gynecology, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.ORCID 0000-0002-4670-018X
Joshua P NederveenDepartment of Pediatrics, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.
Mark A TarnopolskyDepartment of Pediatrics, McMaster University Medical Center (MUMC), Hamilton, ON L86 4L8, Canada.ORCID 0000-0003-0312-3746

Funding

2023 Hamilton Health Sciences Foundation Gala award ($40,000) awarded to Dr. Mark TarnopolskyCanadian Institute of Health Research (CIHR) Dr. Tarnopolsky (# 143325)
6 · The paper itself

Abstract

Ovarian aging is characterized by mitochondrial dysfunction, oxidative stress, and inflammation. The development of adjunctive treatments that mitigate age-related subfertility is warranted. We examined the benefits of nutraceutical supplementation (FE; Fertility Enhancer) with mitochondrial antioxidants, anti-inflammatory agents, metabolic activators, vitamins and minerals, and amino acids on ovarian aging, metabolic activity, and reproductive success in young (Y; 6-month-old) and middle-aged (O; 11-month-old) female C57BL/6J mice. The mice were fed calorie- and macronutrient-matched diets w/wo the FE supplement for three months and harem mated twice. Daily FE supplementation promoted significant body re-composition, including loss of white adipose tissue (gWAT: -36% vs. CON,

Indexed as

AntioxidantsDietary SupplementsOvaryReproductionAgingAnimalsAnti-Inflammatory AgentsBiomarkersDietEnergy MetabolismFemaleMiceMice, Inbred C57BLMitochondriaMuscle, SkeletalOxidative StressAnti-Inflammatory AgentsAntioxidantsBiomarkersVitaminsagingantioxidantsfatfertilityinflammationmitochondriamusclenutraceuticalsobesityoxidative stress

Identifiers

PMID41008565
PMCPMC12466991

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.