ArticleBiomolecules2025
Pharmacological Characterization of the Novel CRF1 Receptor Antagonist, Thiazolo[4,5-d] Pyrimidine Analog, M43.
Spyridon Marios Giatro, George Komontachakis, Aikaterini Kalantidou, Nastazia Lesgidou, Vlasios Karageorgos, Mohamed Teleb, Md Rabiul Islam, Thomas Mavromoustakos, Hesham Fahmy, Maria Venihaki and 2 more
Abstract read
In one paragraphArticle in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Spyridon Marios GiatroDepartment of Biomedical Engineering, University of West Attica, 12210 Egaleo, Greece.ORCID 0009-0004-2773-0916 George KomontachakisDepartment of Pharmacology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Aikaterini KalantidouDepartment of Clinical Chemistry, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Nastazia LesgidouDepartment of Biomedical Engineering, University of West Attica, 12210 Egaleo, Greece.ORCID 0009-0006-7200-0714 Vlasios KarageorgosDepartment of Pharmacology, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0001-7380-9677 Mohamed TelebDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Md Rabiul IslamDepartment of Pharmaceutical Science, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings, SD 57007, USA.
Thomas MavromoustakosDepartment of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0001-5309-992X Hesham FahmyDepartment of Pharmaceutical Science, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings, SD 57007, USA.
Maria VenihakiDepartment of Clinical Chemistry, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0002-3789-8032 Minos-Timotheos MatsoukasDepartment of Biomedical Engineering, University of West Attica, 12210 Egaleo, Greece.ORCID 0000-0002-4642-8163 George LiapakisDepartment of Pharmacology, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0003-2423-3135 Funding
H.F.R.I 25255SARF 10674
6 · The paper itselfAbstract
The corticotropin-releasing factor (CRF) and its type 1 receptor (CRF
Indexed as
PyrimidinesReceptors, Corticotropin-Releasing HormoneThiazolesAnimalsCell ProliferationCRF Receptor, Type 1Cyclic AMPHEK293 CellsHumansMiceMolecular Docking SimulationRAW 264.7 CellsCRF Receptor, Type 1Cyclic AMPPyrimidinesReceptors, Corticotropin-Releasing HormoneThiazolescorticotropin-releasing factornon-peptide antagonistsreceptorsignalingstructure
Identifiers
PMID41008572
PMCPMC12467512
What Socratic holds
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LicenceCC BY
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