Evidence map›Paper›PMID 41008645›Full record

ArticleBiomolecules2025

Exploring the Inhibitory Potential of Six Porphyrin Compounds Against α-Amylase and α-Glucosidase Linked to Diabetes.

Shuo Zhang, Zi Liu, Qiurui Ma, Yangyuxin Liu, Shuren Yin, Zhihan Zhou, Jie Zhou, Helong Bai, Tianjiao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuo ZhangCollege of Chemistry, Changchun Normal University, Changchun 130032, China.
Zi LiuCollege of Chemistry, Changchun Normal University, Changchun 130032, China.
Qiurui MaCollege of Chemistry, Changchun Normal University, Changchun 130032, China.
Yangyuxin LiuCollege of Chemistry, Changchun Normal University, Changchun 130032, China.
Shuren YinCollege of Chemistry, Changchun Normal University, Changchun 130032, China.
Zhihan ZhouCollege of Chemistry, Changchun Normal University, Changchun 130032, China.
Jie ZhouCollege of Chemistry, Changchun Normal University, Changchun 130032, China.
Helong BaiCollege of Chemistry, Changchun Normal University, Changchun 130032, China.ORCID 0009-0006-7988-9202
Tianjiao LiCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Funding

Technology Research Project of Education Department of Jilin Province, China No. JJKH20241005KJ
6 · The paper itself

Abstract

Diabetes mellitus is a characteristic metabolic disorder with diverse complications. α-Amylase and α-glucosidase, as key digestive enzymes regulating blood glucose, are important targets for diabetes prevention and management through their inhibition. This study investigated the inhibitory effects of six porphyrin compounds (TAPP, TCPP, THPP, Cu-TCPP, Fe-TCPP, Ni-TCPP) on two enzymes through in vitro inhibition assays, spectroscopic experiments, and molecular docking techniques. All six compounds effectively inhibited the activities of both enzymes. For α-amylase, the inhibitory potency (IC

Indexed as

alpha-Amylasesalpha-GlucosidasesDiabetes MellitusGlycoside Hydrolase InhibitorsPorphyrinsHumansMolecular Docking Simulationalpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsPorphyrinsinhibitionporphyrin compoundα-amylaseα-glucosidase

Identifiers

PMID41008645
PMCPMC12467033

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.