Evidence map›Paper›PMID 41008822›Full record

ArticleCancers2025

Transcriptional Analysis of Effusion-Based Lymphoma Supports a Post-Germinal Center Origin and Specific Inflammatory Signal Background.

Vanessa Perez-Silos, Hojung Kim, Chenguang Wang, Alejandro Zevallos-Morales, Anthony Tipton, Pierina Danos-Diaz, Ryan Wilcox, Nathanael Bailey, Nidhi Aggarwal, Savanah Dior Gisriel and 4 more

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In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vanessa Perez-SilosDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-9129-3221
Hojung KimDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-2713-4207
Chenguang WangDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0002-9082-2117
Alejandro Zevallos-MoralesDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-5314-8469
Anthony TiptonDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.
Pierina Danos-DiazDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-9093-4303
Ryan WilcoxDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0002-6420-0760
Nathanael BaileyDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-6747-680X
Nidhi AggarwalDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Savanah Dior GisrielDepartment of Pathology, University of Wisconsin, Madison, WI 53705, USA.
Alexandria Smith-HannahDepartment of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.ORCID 0009-0002-8814-5660
Mina XuDepartment of Pathology, Yale University, New Haven, CT 06520, USA.
John Karl FrederiksenDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-2394-7323
Carlos Murga-ZamalloaDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-2238-5066

Funding

WASp signaling in T-cell lymphomasR01CA293380 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Carlos A. Murga-Zamalloa · 2024 to 2026
$2.5M
NCI NIH HHS R01 CA293380NIH HHS 1R01CA293380-01
6 · The paper itself

Abstract

backgroundEffusion-based lymphoma (EBL) is a rare and aggressive large B-cell lymphoma. It presents as a body cavity effusion without a solid mass, lacks HHV-8 association, and typically expresses CD20.

objectivesTo better understand the biology of this entity, we performed transcriptomic profiling of eight EBL cases.

methodsWe analyzed the cases with the NanoString PanCancer Immune Profiling Panel and compared the results with publicly available datasets representing follicular lymphoma (FL), mantle cell lymphoma (MCL), and large B-cell lymphoma (LBCL) subtypes.

resultsUnsupervised clustering and differential expression analysis revealed that EBL cases cluster transcriptionally with the LBCL group. Lymphoma-specific signaling pathway enrichment (SignatureDB) predominantly identified non-germinal center (activated B-cell-type) pathways. In addition, KEGG pathway analyses revealed enrichment in specific inflammatory and immune response pathways that are associated with B-cell lymphoma development in the setting of chronic inflammation, including those linked to Toll-like receptor and NF-κB signaling.

conclusionsThese findings support a post-germinal center origin for EBL, which arises in a background of chronic inflammation and persistent antigen stimulation.

Indexed as

chronic inflammation lymphomaeffusion-based lymphomaHHV-8 negativetranscriptional profile

Identifiers

PMID41008822
PMCPMC12468710

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.