Evidence map›Paper›PMID 41008853›Full record

ArticleCancers2025

Cytokine Profiling of Children, Adolescents, and Young Adults Newly Diagnosed with Sarcomas Demonstrates the Role of IL-1β in Osteosarcoma Metastasis.

Laurel Kastner, William Kandalaft, Aakash Mahant Mahant, Jessica Crimella, Sydney Hakim, Xiao P Peng, Michael S Isakoff, Masanori Hayashi, David M Loeb

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Laurel KastnerDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-3562-6690
William KandalaftDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Aakash Mahant MahantDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-0530-122X
Jessica CrimellaMoffitt Cancer Center, Tampa, FL 33612, USA.
Sydney HakimDepartment of Pediatrics-Hematology/Oncology and Bone Marrow Transplantation, University of Colorado, Aurora, CO 80045, USA.
Xiao P PengDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-7738-1150
Michael S IsakoffConnecticut Children's Medical Center, University of Connecticut School of Medicine, Hartford, CT 06106, USA.ORCID 0000-0003-4790-9919
Masanori HayashiDepartment of Pediatrics-Hematology/Oncology and Bone Marrow Transplantation, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0002-9508-0159
David M LoebDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-7319-5000

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
Patient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Vinayaka R. Prasad · 2017 to 2026
$28.3M
Targeting DKK-1 To Prevent Osteosarcoma MetastasisR01CA262802 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI LOEB, DAVID M. · 2021 to 2025
$3.3M
NCI NIH HHS 2P30CA013330NCI NIH HHS 5R01CA262802NCI NIH HHS P30 CA013330NCI NIH HHS R01 CA262802NIAID NIH HHS P30 AI124414NIH HHS 5P30AI124414-05
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkerscytokinesEwing sarcomaIL-1Bimmunotherapyluminexosteosarcomapediatric cancersarcoma

Identifiers

PMID41008853
PMCPMC12468999

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.