ArticleCancers2025
Poor Oral Health and Risk of Respiratory Tract Cancer: A Prospective Cohort Study from the UK Biobank.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
BACKGROUND/
objectivesThe individual and combined effects of diverse dental problems on site-specific respiratory tract cancer remain insufficiently addressed. This study investigated the associations between six oral conditions-dentures, loose teeth, painful gums, bleeding gums, toothache, and mouth ulcers-and the risk of developing cancers of the lung, bronchus, larynx, and trachea, both individually and collectively.
methodsThis prospective cohort study, utilizing baseline data from the UK Biobank, analyzed 438,762 participants aged 40-69 years. Multivariable Cox proportional hazards models were employed to estimate hazard ratios (HRs) and 95% CIs for incident respiratory tract cancer associated with individual oral conditions and their cumulative impact. Effect modification by sociodemographics, lifestyle, and underlying medical conditions was further assessed.
resultsDuring the follow-up (median = 11.0 years), 3568 participants developed respiratory tract cancer. After adjusting for confounders, including smoking history, individuals with any oral issues exhibited a 35-76% higher risk of respiratory tract cancer (HR [95% CI]: 1.35 [1.25-1.46] for the total risk, 1.34 [1.24-1.45] for bronchus/lung cancer, and 1.76 [1.23-2.52] for laryngeal cancer). Dentures (1.48 [1.36-1.60]), loose teeth (1.36 [1.20-1.54]), and painful gums (1.25 [1.04-1.50]) had a strong association with respiratory tract cancer. The overall risk escalated progressively with the number of concurrent problems (HR [95% CI] of 1.32 [1.22-1.43] for one, 1.42 [1.25-1.62] for two, 1.57 [1.23-1.98] for three, and 1.71 [1.16-2.50] for ≥four). Associations were pronounced among smokers (
conclusionsPoor oral health is linked to a heightened risk of respiratory tract cancer, especially when coupled with smoking, underscoring the importance of oral health promotion in cancer prevention strategies.
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