Evidence map›Paper›PMID 41008923›Full record

ArticleCancers2025

Physiopathological Features in a Three-Dimensional In Vitro Model of Hepatocellular Carcinoma: Hypoxia-Driven Oxidative Stress and ECM Remodeling.

Maria Giovanna Rizzo, Enza Fazio, Claudia De Pasquale, Emanuele Luigi Sciuto, Giorgia Cannatà, Cristiana Roberta Multisanti, Federica Impellitteri, Federica Gilda D'Agostino, Salvatore Pietro Paolo Guglielmino, Caterina Faggio and 1 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria Giovanna RizzoDepartment of Chemical Sciences, Biological, Pharmaceutical and Environmental, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy.ORCID 0000-0001-6781-6387
Enza FazioDepartment of Mathematics and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy.ORCID 0000-0001-9132-7073
Claudia De PasqualeLaboratory of Immunology, Department of Human Pathology DETEV, Messina University, 98166 Messina, Italy.
Emanuele Luigi SciutoDepartment of Chemical Sciences, Biological, Pharmaceutical and Environmental, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy.ORCID 0000-0003-4972-9874
Giorgia CannatàDepartment of Chemical Sciences, Biological, Pharmaceutical and Environmental, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy.
Cristiana Roberta MultisantiDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci snc, 98168 Messina, Italy.ORCID 0000-0002-6283-2502
Federica ImpellitteriDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci snc, 98168 Messina, Italy.ORCID 0000-0003-1694-2281
Federica Gilda D'AgostinoThoracic Surgery Unit, Papardo Hospital, 98158 Messina, Italy.ORCID 0009-0006-1303-8077
Salvatore Pietro Paolo GuglielminoDepartment of Chemical Sciences, Biological, Pharmaceutical and Environmental, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy.
Caterina FaggioDepartment of Chemical Sciences, Biological, Pharmaceutical and Environmental, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy.ORCID 0000-0002-0066-2421
Sabrina ConociDepartment of Chemical Sciences, Biological, Pharmaceutical and Environmental, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ECM remodelinghepatocellular carcinoma (HCC)hypoxiapathophysiologythree-dimensional (3D) modeltumor microenvironment

Identifiers

PMID41008923
PMCPMC12468481

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.