Evidence map›Paper›PMID 41008991›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Oxidative Stress-Mediated DNA Damage Induced by Ionizing Radiation in Modern Computed Tomography: Evidence for Antioxidant-Based Radioprotective Strategies.

Baltasar Ramos, Jorge Gómez-Cayupán, Isidora Aranis, Esperanza García Tapia, Constanza Coghlan, María-José Ulloa, Santiago Gelerstein Claro, Katherine Urbina, Gonzalo Espinoza, José De Grazia and 6 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Baltasar RamosRadiology Department, University of Chile Clinical Hospital, Carlos Lorca 999, Independencia, Santiago 8380453, Chile.ORCID 0009-0001-6750-1518
Jorge Gómez-CayupánHuman Genetics Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia, Santiago 8380453, Chile.ORCID 0009-0006-2505-6862
Isidora AranisSchool of Medicine, Faculty of Medicine, University of Chile, Independencia, Santiago 8380453, Chile.
Esperanza García TapiaSchool of Medicine, Faculty of Medicine, University of Chile, Independencia, Santiago 8380453, Chile.
Constanza CoghlanSchool of Medicine, Faculty of Medicine, University of Chile, Independencia, Santiago 8380453, Chile.
María-José UlloaRadiology Department, University of Chile Clinical Hospital, Carlos Lorca 999, Independencia, Santiago 8380453, Chile.
Santiago Gelerstein ClaroSchool of Medicine, Faculty of Medicine, University of Chile, Independencia, Santiago 8380453, Chile.ORCID 0009-0005-6122-1688
Katherine UrbinaHuman Genetics Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia, Santiago 8380453, Chile.
Gonzalo EspinozaRadiology Department, University of Chile Clinical Hospital, Carlos Lorca 999, Independencia, Santiago 8380453, Chile.
José De GraziaRadiology Department, University of Chile Clinical Hospital, Carlos Lorca 999, Independencia, Santiago 8380453, Chile.
Jorge DíazRadiology Department, University of Chile Clinical Hospital, Carlos Lorca 999, Independencia, Santiago 8380453, Chile.ORCID 0000-0003-4989-8547
Prisco PiscitelliDepartment of Psychology and Health Sciences, Pegaso University, Piazza Trieste e Trento 48, 80132 Naples, Italy.ORCID 0000-0003-4556-6182
Daniel CastroRadiology Department, University of Chile Clinical Hospital, Carlos Lorca 999, Independencia, Santiago 8380453, Chile.
Marcia ManterolaHuman Genetics Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia, Santiago 8380453, Chile.ORCID 0000-0002-5802-1301
Ramón RodrigoLaboratory of Oxidative Stress and Nephrotoxicity, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia, Santiago 8380453, Chile.ORCID 0000-0003-1724-571X
Camilo G SotomayorRadiology Department, University of Chile Clinical Hospital, Carlos Lorca 999, Independencia, Santiago 8380453, Chile.ORCID 0000-0001-6835-6386

Funding

Agencia Nacional de Investigación y Desarrollo (ANID) 11251606
6 · The paper itself

Abstract

Computed tomography (CT) is fundamental to modern medicine, yet ionizing radiation (IR) exposure causes DNA damage. Although often underestimated, at current doses, CT may account for ~5% of new cancer diagnoses. Complementary radioprotective approaches beyond dose reduction are needed. We conducted a prospective observational study to characterize IR-induced oxidative stress (OS)-mediated DNA damage in modern CT to explore potential antioxidant-based radioprotective strategies. In volunteers not exposed to IR (A

Indexed as

antioxidantscomputed tomographyDNA damageionizing radiationoxidative stress

Identifiers

PMID41008991
PMCPMC12466383

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.