Evidence map›Paper›PMID 41009342›Full record

ReviewInternational journal of molecular sciences2025

Age-Driven Genetic and Epigenetic Heterogeneity in B-ALL.

Yoana Veselinova, Manel Esteller, Gerardo Ferrer

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yoana VeselinovaCancer Epigenetics, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Spain.
Manel EstellerCancer Epigenetics, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Spain.ORCID 0000-0003-4490-6093
Gerardo FerrerCancer Epigenetics, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Spain.ORCID 0000-0002-4084-6815

Funding

Deutsche José Carreras Leukämie Stiftung DJCLS 03 R/2024
6 · The paper itself

Abstract

B-cell acute lymphoblastic leukemia (B-ALL) remains a major clinical challenge in hematologic oncology, characterized by a continuous evolution of molecular drivers that shape its heterogeneity across the age spectrum. Pediatric B-ALL is generally associated with high cure rates, while adult forms of the disease are often more aggressive and less responsive to treatment. This review examines the age-specific genetic and epigenetic landscapes that contribute to this disparity, revealing how the nature and timing of molecular alterations point to fundamentally different leukemogenic processes. Favorable genetic aberrations, such as

Indexed as

Epigenesis, GeneticGenetic HeterogeneityPrecursor B-Cell Lymphoblastic Leukemia-LymphomaAge FactorsDNA MethylationHumansMutationadultB-cell acute lymphoblastic leukemiaepigeneticsgeneticspediatricyoung adult

Identifiers

PMID41009342
PMCPMC12469455

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.